AI Article Synopsis
- 'Globemaster' is a hybrid ornamental plant, and its bulbs were analyzed for their chemical compounds through a systematic study.
- The researchers isolated 27 steroidal glycosides from the bulbs, identifying various classes, including spirostanol and furostanol glycosides, using NMR spectroscopic data.
- Certain isolated compounds showed cytotoxic effects on various cancer cell lines, with specified inhibitory concentrations ranging from 1.3 to 49 µM.
Article Abstract
'Globemaster' is an ornamental hybrid cultivar whose parent plants are and . The chemical constituents of 'Globemaster' bulbs have not yet been examined; thus, a systematic phytochemical investigation was undertaken herein. A series of chromatographic separations of the MeOH extract of 'Globemaster' bulbs afforded 27 steroidal glycosides (-), which are classified into 23 spirostanol glycosides (- and -), two furostanol glycosides ( and ), a pregnane glycoside (), and a cholestane glycoside (). The structures of the hitherto undescribed compounds (-) were determined from the two-dimensional NMR spectroscopic data and hydrolysis. The cytotoxicity of the isolated compounds (-) toward HL-60 human promyelocytic leukemia cells, A549 human adenocarcinoma lung cancer cells, and SBC-3 human small-cell lung cancer cells was evaluated. Compounds , , , , and exhibited cytotoxicity toward all cell lines in a dose-dependent manner, with IC values in the 1.3-49 µM range.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488941 | PMC |
| http://dx.doi.org/10.3390/molecules28176248 | DOI Listing |
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