Background: Ovarian tissue cryopreservation and transplantation are the only available fertility techniques for prepubertal girls with cancer. Though autotransplantation carries a risk of reintroducing malignant cells, it can be avoided by identifying minimal infiltrative disease (MID) within ovarian tissue.
Methods: A broad search for peer-reviewed articles in the PubMed database was conducted in accordance with PRISMA guidelines up to March 2023. Search terms included 'minimal residual disease', 'cryopreservation', 'ovarian', 'cancer' and synonyms.
Results: Out of 542 identified records, 17 were included. Ovarian tissues of at least 115 girls were evaluated and categorized as: hematological malignancies ( = 56; 48.7%), solid tumors ( = 42; 36.5%) and tumors of the central nervous system ( = 17; 14.8%). In ovarian tissue of 25 patients (21.7%), MID was detected using RT-qPCR, FISH or multicolor flow cytometry: 16 of them (64%) being ALL ( rearrangements with/without , , , fusion transcripts), 3 (12%) Ewing sarcoma ( fusion transcript, rearrangements), 3 (12%) CML ( fusion transcript, ) and 3 (12%) AML (leukemia-associated immunophenotypes, fusion transcript) patients.
Conclusion: While the majority of malignancies were found to have a low risk of containing malignant cells in ovarian tissue, further studies are needed to ensure safe implementation of future fertility restoration in clinical practice.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486797 | PMC |
| http://dx.doi.org/10.3390/cancers15174199 | DOI Listing |
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