AI Article Synopsis
- - The study focuses on psoriasis, a chronic skin disease influenced by systemic inflammation, and examines specific blood ratio indicators (NLR, NMR, PLR, SII) in patients undergoing treatment with biological agents.
- - Researchers analyzed clinical data from 209 psoriasis patients and found that after three months of treatment, key inflammation markers showed significant reductions compared to initial levels.
- - Results suggest that the blood ratios (NLR, NMR, PLR, SII) can effectively monitor treatment progress in psoriasis, particularly when patients are using TNF-α blockers like adalimumab and etanercept.
Article Abstract
Background: Psoriasis is a chronic immune-mediated skin disease in which systemic inflammation plays an important role in its pathogenesis. In recent years, the neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-monocyte ratio (NMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were shown to be important indicators of inflammation. This study aimed to investigate the NLR, NMR, PLR, and SII levels in psoriasis patients treated with biological agents.
Method: Clinical and biochemical data of 209 patients who received systemic therapy for psoriasis were obtained by retrospectively reviewing their medical records. The NLR, NMR, PLR, and SII values were calculated from the hemogram values of the patients.
Results: In the third month of follow-up, the mean CRP, NLR, NMR, PLR, and SII values were significantly decreased compared with the baseline values. The SII values showed strong positive correlations with the NLR, NMR, and PLR. Adalimumab, etanercept, and infliximab, which are TNF-α blockers, were observed to be more effective on the PLR and NLR, and especially the NMR.
Conclusions: The NLR, NMR, PLR, and SII, which are data derived from routine blood tests, can be used in the monitoring of the treatment of psoriasis, especially with TNF-α blockers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10488109 | PMC |
| http://dx.doi.org/10.3390/jcm12175452 | DOI Listing |
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