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Heart Rate Variability as a Surrogate Marker of Severe Chronic Coronary Syndrome in Patients with Obstructive Sleep Apnea. | LitMetric

AI Article Synopsis

  • Obstructive sleep apnea (OSA) is connected to heart problems like chronic coronary syndrome (CCS), and both can change how the heart beats.
  • In a study of 32 OSA patients, researchers looked at heart rate patterns in those with severe CCS compared to those without.
  • They found that patients with both OSA and severe CCS had lower heart rate variability, suggesting CCS significantly affects heart health in OSA patients.

Article Abstract

Background And Objectives: Obstructive sleep apnea (OSA) is a known risk factor for chronic coronary syndrome (CCS). CCS and OSA are separately associated with significant changes in heart rate variability (HRV). In this proof-of-concept study, we tested whether HRV values are significantly different between OSA patients with concomitant severe CCS, and OSA patients without known CCS.

Material And Methods: The study comprised a retrospective assessment of the historical and raw polysomnography (PSG) data of 32 patients who presented to a tertiary university hospital with clinical complaints of OSA. A total of 16 patients (four females, mean age 62.94 ± 2.74 years, mean body mass index (BMI) 31.93 ± 1.65 kg/m) with OSA (median apnea-hypopnea index (AHI) 39.1 (30.5-70.6)/h) and severe CCS were compared to 16 patients (four females, mean age 62.35 ± 2.06 years, mean BMI 32.19 ± 1.07 kg/m) with OSA (median AHI 40 (30.6-44.5)/h) but without severe CCS. The short-long-term HRV (in msec) was calculated based on the data of a single-lead electrocardiogram (ECG) provided by one full-night PSG, using the standard deviation of the NN, normal-to-normal intervals (SDNN) and the heart rate variability triangular index (HRVI) methods, and compared between the two groups.

Results: A significant reduction ( < 0.05) in both SDNN and HRVI was found in the OSA group with CCS compared to the OSA group without CCS.

Conclusions: Severe CCS has a significant impact on short-long-term HRV in OSA patients. Further studies in OSA patients with less-severe CCS may shed more light onto the involved mechanistic processes. If confirmed in future larger studies, this physiologic metric has the potential to provide a robust surrogate marker of severe CCS in OSA patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10486866PMC
http://dx.doi.org/10.3390/diagnostics13172838DOI Listing

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