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Clozapine treatment continues to be recognized as the gold standard for managing treatment-resistant schizophrenia. Combining clozapine with other antipsychotics (i.e.
View Article and Find Full Text PDFPrevalence and Factors Associated with Hypersalivation in Schizophrenia Inpatients Treated with Clozapine: A Retrospective Study.
Hosp Pharm
December 2024
Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, Thailand.
Hypersalivation, or excessive production and secretion of saliva, can result from associated disorders or adverse drug reactions. It significantly impacts physical health, psychosocial well-being, and quality of life. Clozapine, a gold standard for treatment-resistant schizophrenia, is known to cause hypersalivation in some patients.
View Article and Find Full Text PDFAlterations in regional homogeneity in schizophrenia patients comorbid with metabolic syndrome treated with risperidone or clozapine.
J Psychiatr Res
November 2024
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China. Electronic address:
The neuroimaging mechanisms that arise in patients with schizophrenia and comorbid metabolic syndrome (MetS) remain poorly understood. This study was devised to examine potential alterations in regional homogeneity (ReHo) that arise in schizophrenia patients with comorbid MetS undergoing risperidone or clozapine treatment. In total, 43 schizophrenia patients undergoing risperidone or clozapine treatment were enrolled in this study, of whom 20 had comorbid MetS (SZ-MetS) while 23 did not (SZ-nMetS).
View Article and Find Full Text PDFAlert prescribing of clozapine: a comparison of five drug-drug interaction sources.
Ther Adv Drug Saf
December 2024
University Psychiatric Center KU Leuven, Z.org KU Leuven, Kortenberg, Belgium.
Article Synopsis
- Clozapine is an antipsychotic for schizophrenia that has serious side effects, making drug-drug interaction (DDI) databases important for clinician reference.
- This study analyzed DDI information from five different databases to assess their agreement on potential interactions with clozapine.
- Out of 183 potential DDIs identified, only 47.5% showed consensus across the databases, highlighting significant discrepancies that could affect patient safety and prescribing practices.
Lamotrigine as a preventive agent against recurrent catatonia in adult-onset Niemann-Pick Type-C disease: a case report.
Neurocase
December 2024
Department of Psychiatry, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Article Synopsis
- - Niemann-Pick Type-C (NPC) disease can lead to serious neuropsychiatric issues, including catatonia, which doesn't always respond well to standard treatments like antipsychotics.
- - A patient with adult-type NPC developed catatonia that persisted despite various medications, but improved significantly with electroconvulsive therapy (ECT).
- - Combining ECT with lorazepam managed the catatonia, and adding lamotrigine led to full remission for eight months, suggesting lamotrigine's potential benefits in treating recurrent catatonia.
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