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Overcoming three-dimensional challenges through objective decomposition and virtual-digital design: A multidisciplinary case on hypodontia treatment.
J World Fed Orthod
March 2025
Assistant professor, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China. Electronic address:
A 15-year-old female sought multidisciplinary treatment for hypodontia, three-dimensional problems, deep overbite, multiple occlusal interferences, and collapse of the occlusion. Through virtual-digital design with objective decomposition, this patient underwent five steps of orthodontic treatment under the guidelines of the principles: removal of occlusal restriction is a prerequisite; transverse problems are solved first; then sagittal problems; and vertical correction runs through the treatment. After orthodontic and prosthetic treatment, aesthetic appearance and functional occlusion were achieved.
View Article and Find Full Text PDFComprehensive Course on Clinical Study Data Management for Medical Informatics Students.
Appl Clin Inform
March 2025
Chair of IT Infrastructure for Translational Medical Research, University of Augsburg, Augsburg, Germany.
Background: Effective data management is critical in medical informatics research, ensuring the success and integrity of clinical studies. However, students often lack comprehensive training in this area, highlighting the need for tailored educational programs.
Objectives: This study aims to introduce a proposed course focused on data management for medical informatics students.
Machine-learning heat flux closure for multi-moment fluid modeling of nonlinear Landau damping.
Proc Natl Acad Sci U S A
March 2025
Department of Astronomy, Center for Space Physics, Boston University, Boston, MA 02215.
Nonlinear plasma physics problems are usually simulated through comprehensive modeling of phase space. The extreme computational cost of such simulations has motivated the development of multi-moment fluid models. However, a major challenge has been finding a suitable fluid closure for these fluid models.
View Article and Find Full Text PDFRBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.
PLoS Comput Biol
March 2025
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America.
Advancements with cost-effective, high-throughput omics technologies have had a transformative effect on both fundamental and translational research in the medical sciences. These advancements have facilitated a departure from the traditional view of human red blood cells (RBCs) as mere carriers of hemoglobin, devoid of significant biological complexity. Over the past decade, proteomic analyses have identified a growing number of different proteins present within RBCs, enabling systems biology analysis of their physiological functions.
View Article and Find Full Text PDFData Obfuscation Through Latent Space Projection for Privacy-Preserving AI Governance: Case Studies in Medical Diagnosis and Finance Fraud Detection.
JMIRx Med
March 2025
Stelmith, LLC, 2333 Aberdeen Pl, Carollton, TX, 75007, United States, 1 9459001314.
Background: The increasing integration of artificial intelligence (AI) systems into critical societal sectors has created an urgent demand for robust privacy-preserving methods. Traditional approaches such as differential privacy and homomorphic encryption often struggle to maintain an effective balance between protecting sensitive information and preserving data utility for AI applications. This challenge has become particularly acute as organizations must comply with evolving AI governance frameworks while maintaining the effectiveness of their AI systems.
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