AI Article Synopsis
- Detection of nucleobases is crucial for DNA sequencing, a key objective of the Human Genome Project.
- A proposed biosensor using TMN-doped graphene nanoribbons shows that all five nucleobases can be detected through specific adsorption energy calculations.
- The sensor identifies bases T, C, and U at lower voltages, while A and G require higher voltage, paving the way for improved biosensing in genomic applications.
Article Abstract
Detection of nucleobases is of great significance in DNA sequencing, which is one of the main goals of the Human Genome Project. By employing the nonequilibrium Green function method combined with density functional theory, we proposed a biosensor based on the TMN (TM = Ni, Cu) embedded graphene nanoribbons for nucleobase detection. The adsorption energy calculations show that all five nucleobases are physisorbed on the TMN-doped graphene nanoribbons. Utilizing the distinction of current, the bases T, C, and U can be gradually detected at the biases of 0.4, 0.6, and 0.8 V by NiN-doped graphene nanoribbons, respectively. The bases A and G can be finally distinguished by CuN-doped graphene nanoribbons under an external bias of not less than 0.8 V. The identification of individual nucleobases at specific biases could provide a novel mechanism for the further development of biosensors in rapid genome sequencing applications.
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| http://dx.doi.org/10.1021/acs.jpcb.3c02661 | DOI Listing |
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