AI Article Synopsis
- - The study explored the use of methanolic extracts from Stephania glabra tubers to create nanoparticles (Sg-AgNP, Sg-CuONP, and Sg-BNP) aimed at treating prostate cancer.
- - These nanoparticles demonstrated strong cytotoxic effects on prostate cancer cells (PC3) while being safe for normal cells, promoting apoptosis through increased reactive oxygen species (ROS) and mitochondrial issues.
- - Among the different nanoparticle types, Sg-BNP showed the most effective anticancer properties in both 2D and 3D tumor models, with notable shrinkage of 3D prostate tumor spheroids after treatment.
Article Abstract
In pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.19, and 25.59 nm of Sg-AgNP, Sg-CuONP, and Sg-BNP, respectively. Interestingly, these nanoparticles exhibited significant cytotoxicity toward the prostate cancer (PC3) cell line while being non-toxic toward normal cells. The nanoparticles were capable of inducing apoptosis in PC3 cells by enhancing reactive oxygen species (ROS) generation and mitochondrial depolarization. Furthermore, the shrinkage of 3D prostate tumor spheroids was observed after 4 days of treatment with these green nanoparticles. The 3D model system was less susceptible to nanoparticles as compared to the 2D model system. Sg-BNP showed the highest anticancer potential on 2D and 3D prostate cancer models.
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| http://dx.doi.org/10.1007/s12010-023-04700-w | DOI Listing |
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