AI Article Synopsis
- The study aimed to assess the risk of endometrial cancer (EC) among women with BRCA 1/2 mutations who underwent risk-reducing salpingo-oophorectomy (RRSO).
- Data was collected from 857 women from four hospitals in Catalonia, Spain, over a 20-year period, comparing cases of EC against expected cases based on regional cancer registry statistics.
- Results showed a slightly increased risk, with eight cases of EC identified post-RRSO, leading to the conclusion that routine hysterectomy is not necessary for BRCA 1/2 carriers after RRSO, as their risk of EC is similar to general expectations.
Article Abstract
Objective: To know the risk of endometrial cancer (EC) in a population of women with BRCA 1/2 pathogenic or likely pathogenic variants after risk-reducing salpingo-oophorectomy (RRSO).
Methods: The study cohort included data from 857 women with BRCA mutations who underwent RRSO visited four hospitals in Catalonia, Spain, from January 1, 1999 to April 30, 2019. Standardized incidence ratio (SIR) of EC was calculated in these patients using data from a regional population-based cancer registry.
Results: After RRSO, eight cases of EC were identified. Four in BRCA 1 carriers and four in BRCA2 carriers. The expected number of cases of EC was 3.67 cases, with a SIR of 2.18 and a 95% CI (0.93-3.95).
Conclusions: In our cohort, the risk of EC in BRCA1/2 carriers after RRSO is not greater than expected. Hysterectomy is not routinely recommended for these patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981602 | PMC |
| http://dx.doi.org/10.1007/s12094-023-03312-4 | DOI Listing |
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