Purpose: To describe a case of linezolid toxic optic neuropathy in a 71-year-old female and review the relevant literature.
Observations: An adult female with progressive, symmetric vision loss was hypothesized to have linezolid toxic optic neuropathy. Following cessation of linezolid, the patient experienced improvement in visual function over two months.
Conclusions And Importance: Patients diagnosed with linezolid toxic optic neuropathy can expect some return of visual function after cessation. The degree of return does not correlate to the cumulative dose of the drug. The goal of this study was to summarize and add to the current body of literature on the topic.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480323 | PMC |
http://dx.doi.org/10.1016/j.ajoc.2023.101922 | DOI Listing |
J Hazard Mater
December 2024
Laboratory of Environmental Pollution Control, Department of Chemistry, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, Thessaloniki 57001, Greece. Electronic address:
Antibiotics are prevalent in wastewater treatment plants and are subsequently released into aquatic environments, threatening aquatic organisms and compromising drinking water quality. Consequently, investigating their environmental fate and developing efficient removal processes is crucial. The degradation and fate of the antibiotic drug linezolid were investigated, focusing on the formation of transformation products (TPs).
View Article and Find Full Text PDFJ Chemother
December 2024
Department of Pharmacy, the First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
To promote the accurate administration of linezolid, this study aimed to evaluate its dosage regimens in critically ill patients with varying renal functions. This evaluation was based on a combined analysis of pharmacokinetic (PK), pharmacodynamic (PD), and toxicodynamic (TD) indices. The percentage of therapeutic target attainment (PTTA) was used as the index for PK/PD/TD, defined as simultaneously meeting two PK/PD criteria (AUC/MIC ≥ 100 and C between 2.
View Article and Find Full Text PDFBiomed Environ Sci
November 2024
Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Expert Opin Drug Saf
December 2024
Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background: Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), and Acute Generalized Exanthematous Pustulosis (AGEP), pose significant therapeutic challenges. Vancomycin and linezolid have been linked to these life-threatening conditions, necessitating a better understanding of their associated risks.
Methods: We conducted a retrospective analysis using data from the FDA Adverse Event Reporting System (FAERS) database.
Oxf Med Case Reports
December 2024
Haematology, Colchester Hospital, East Suffolk and North Essex NHS Foundation Trust, Turner Road, Colchester, United Kingdom.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!