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Enhancing cardiac regeneration: direct reprogramming of fibroblasts into myocardial-like cells using extracellular vesicles secreted by cardiomyocytes.
Mol Cell Biochem
December 2024
Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Henan Xinxiang, 453003, People's Republic of China.
To investigate the promoting effect of extracellular vesicles derived from myocardial cells (CM-EVs) on the reprogramming of cardiac fibroblasts (CFs) into cardiomyocyte-like cells (iCMs) and their therapeutic effect on myocardial infarction (MI) in rats. Cell experiments: The differential adhesion method was used to obtain Sprague Dawley (SD) suckling rat CFs and cardiomyocytes (CMs), while the ultracentrifugation method was used to obtain CM-EVs. Transmission electron microscopy and nanoparticle tracking technology were used to analyze and determine the morphology and particle size of CM-EVs.
View Article and Find Full Text PDFChinese acupuncture: A potential treatment for autism rat model via improving synaptic function.
Heliyon
September 2024
Fujian Maternity and Child Health Hospital, Fuzhou, 350108, Fujian, China.
Article Synopsis
- The study investigates the effects of scalp acupuncture on autism symptoms in a rat model created using valproic acid, comparing behaviors across three groups: one treated with acupuncture, one untreated, and a wild-type control group.
- Results indicated that acupuncture significantly improved anxiety-like behavior, social interaction, and overall activity in the rat model compared to the untreated group.
- RNA sequencing analysis revealed distinct differences in gene expression related to synaptic function and neural signaling among the groups, suggesting potential mechanisms for the observed behavioral improvements following acupuncture treatment.
Preconditioning of Human Umbilical Cord Mesenchymal Stem Cells with a Histone Deacetylase Inhibitor: Valproic Acid.
Balkan Med J
September 2024
Department of Histology and Embryology, İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, İstanbul, Türkiye.
Background: Mesenchymal stem cells (MSCs) play a key role in regenerative medicine due to their capacity to differentiate into multiple cell lines, regulate the immune system, and exert paracrine effects. The therapeutic impact of MSCs is primarily mediated through their secretome. The secretory and therapeutic potential of MSCs can be improved through preconditioning, which entails the application of hypoxic environments, 3-dimensional cell cultures, and pharmacological agents.
View Article and Find Full Text PDFGastrointestinal problems in a valproic acid-induced rat model of autism: From maternal intestinal health to offspring intestinal function.
World J Psychiatry
July 2024
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100000, China.
Article Synopsis
- Autism spectrum disorder (ASD) is a condition that affects how people interact with others and can cause repetitive behaviors, often linked with stomach problems like constipation or diarrhea.
- Researchers wanted to see if the tummy troubles in kids with ASD are connected to their moms having gut issues during pregnancy.
- They found that when pregnant rats were exposed to a certain chemical, it changed their gut health and may have led to similar problems in their babies, suggesting that a mom's gut health might affect her child's gut too.
Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice.
Transl Psychiatry
July 2024
Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City, 133002, Jilin, China.
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for autism spectrum disorder (ASD). Numerous studies have shown that impaired synaptic transmission in the cerebellar cortical circuits is one of the reasons for the social deficits and repetitive behavior seen in ASD. In this study, we investigated the effect of VPA exposure during pregnancy on tactile stimulation-evoked cerebellar mossy fiber-granule cell (MF-GC) synaptic transmission in mice anesthetized with urethane.
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