Triple modular redundancy (TMR) is a robust technique utilized in safety-critical applications to enhance fault-tolerance and reliability. This article focuses on estimating the distribution parameters of a TMR system under step-stress partially accelerated life tests, where each component included in the system follows a Lomax distribution. The study aims to analyze the system's reliability and mean residual lifetime based on the estimated parameters. Various estimation techniques, including maximum likelihood, percentile, least squares, and maximum product of spacings, are explored. Additionally, the optimal stress change time is determined using two criteria. An illustrative example supported by two actual data sets is presented to showcase the methodology's application. By conducting Monte Carlo simulations, the assessment of the estimation methods' effectiveness reveals that the maximum likelihood method outperforms the other three methods in terms of both accuracy and performance, as indicated by the numerical outcomes. This research contributes to the understanding and practical implementation of TMR systems in safety-critical industries, potentially saving lives and preventing catastrophic events.
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http://dx.doi.org/10.1038/s41598-023-41363-3 | DOI Listing |
Eur J Pharm Sci
December 2024
Massachusetts College of Pharmacy and Health Sciences (MCPHS University) Department of Pharmaceutical Sciences, School of Pharmacy, 19 Foster St., Worcester, MA 01608, USA. Electronic address:
Triple-negative breast cancer (TNBC) presents with resistance phenotypes to certain therapies, such as cisplatin, often requiring higher dosing, with associated acquired tumor resistance, renal toxicity, and variable patient responses. A self-emulsifying drug delivery (SEDD) formulation approach was proposed to overcome the limitations of cisplatin in TNBC, focusing on improving intracellular cisplatin and control siRNA uptake as a proof-of-principle of dual drug delivery. Four SEDD formulations were prepared and optimized for cisplatin (o/w) emulsion and FITC-siRNA (w/o) emulsion using pseudo-ternary phase diagrams to facilitate the formation of water-in-oil-water (w/o/w) emulsions.
View Article and Find Full Text PDFSensors (Basel)
November 2024
School of Computer Science, Northwestern Polytechnical University, Xi'an 710000, China.
As maximum power point tracking (MPPT) algorithms have developed towards multi-task intelligent computing, processors in photovoltaic power generation control systems must be capable of achieving a higher performance. However, the challenges posed by the complex environment of photovoltaic fields with regard to processor reliability cannot be overlooked. To address these issues, we proposed a novel approach.
View Article and Find Full Text PDFSci Rep
November 2024
NIMS Institute of Engineering and Technology (NIET), NIMS University, Jaipur, Rajasthan, 303121, India.
Field Programmable Gate Arrays are extensively used in space, military, and commercial sectors due to their reprogrammable nature. In high-safety environments, ensuring fault tolerance is crucial to improving the performance of electronic and computational systems. Common fault-tolerant methods include time redundancy, double modular redundancy, triple modular redundancy, hardware redundancy, self-checking, self-repairing, and Operand Width Aware Hardware Reuse.
View Article and Find Full Text PDFExpert Rev Med Devices
December 2024
Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China.
Objectives: This study aimed to assess the anatomical feasibility of a novel modular triple-branched endograft for aortic arch diseases.
Methods: A cross-sectional study was conducted on 314 patients with aortic arch pathologies treated at a single center from January 2018 to December 2023. Preoperative computed tomography angiography images were analyzed with three-dimensional reconstruction to quantify anatomical features.
Angew Chem Int Ed Engl
November 2024
The Education Ministry Key Lab of Resource Chemistry, Shanghai Frontiers Science Center of Biomimetic Catalysis, and College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.
Photoinduced excited-state Pd catalysis has emerged as an intriguing strategy for unlocking new reactivity potential of simple substrates. However, the related transformations are still limited and the enantiocontrol remains challenging. Organocatalysis displays unique capability in substrate activation and stereocontrol.
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