To evaluate how and from where social risk data are extracted from EHRs for research purposes, and how observed differences may impact study generalizability. Systematic scoping review of peer-reviewed literature that used patient-level EHR data to assess 1 ± 6 social risk domains: housing, transportation, food, utilities, safety, social support/isolation. 111/9022 identified articles met inclusion criteria. By domain, social support/isolation was most often included ( = 68/111), predominantly defined by marital/partner status ( = 48/68) and extracted from structured sociodemographic data ( = 45/48). Housing risk was defined primarily by homelessness ( = 39/49). Structured housing data was extracted most from billing codes and screening tools ( = 15/30, 13/30, respectively). Across domains, data were predominantly sourced from structured fields ( = 89/111) versus unstructured free text ( = 32/111). We identified wide variability in how social domains are defined and extracted from EHRs for research. More consistency, particularly in how domains are operationalized, would enable greater insights across studies.

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