AI Article Synopsis
- - The study aimed to analyze how common chemotherapy-related cognitive impairment (CRCI) is among older breast cancer survivors and what factors might contribute to it.
- - The systematic review found that CRCI affected 18.6% to 27% of older survivors according to tests, with higher self-reported cognitive issues (7.6% to 49%), impacting areas like attention and memory.
- - Factors influencing CRCI included age, education, sleep disorders, anxiety, chemotherapy details, genetics, and lifestyle, highlighting the need for more rigorous studies to validate these findings.
Article Abstract
Aims: To examine the prevalence and associated factors of chemotherapy-related cognitive impairment (CRCI) in older breast cancer survivors (BCS).
Design: Systematic review.
Data Sources: We searched EMBASE, PubMed, PsychInfo, CINAHL, Cochrance Library, Web of Science, CNKI and SinoMed, without language restrictions, for studies published from the establishment of the database to September 2022.
Review Methods: Two researchers independently examined the full texts, data extraction and quality assessment, and any discrepancies were resolved through discussion with a third reviewer. Quality of evidence was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality Scale.
Results: The seven included studies showed that the estimated prevalence of CRCI in older BCS ranged from 18.6% to 27% on objective neuropsychological tests and from 7.6% to 49% on subjective cognitive assessments. The areas most affected were attention, memory, executive functioning and processing speed. CRCI was associated with 10 factors in six categories, including sociodemographic (e.g. age, education level), physiological (e.g. sleep disorders, fatigue and comorbidities), psychological (e.g. anxiety, depression), treatment modalities (e.g. chemotherapy cycles, chemotherapy regimens), genetic (e.g. APOE2, APOE4) and lifestyle factor (e.g. physical inactivity).
Conclusion: CRCI is multifactorial and has a relatively high prevalence. However, the results of subjective and objective cognitive examinations were inconsistent, possibly due to variations in tools used to evaluate different definitions of CRCI. Nevertheless, as there are few published studies of older BCS, this conclusion still require verification by well-designed studies in the future.
Impact: We found that the prevalence of CRCI in older adults is relatively high and multifactorial, providing evidence for further health care for this population.
No Patient Or Public Contribution: There was no patient or public involvement.
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| http://dx.doi.org/10.1111/jan.15842 | DOI Listing |
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