The development of new anti-cancer agents is an urgent necessity nowadays, as it is one of the major causes of mortality worldwide. Many drugs currently used are derived from natural products. Halimanes are a class of bicyclic diterpenoids present in various plants and microorganisms. Many of them exhibit biological activities such as antitumor, antimicrobial, or anti-inflammatory. Among them, -halimic acid is an easily accessible compound, in large quantities, from the ethyl acetate extract of the plant , and it has been used as a starting material in a number of bioactive molecules. In this work, we review all the natural halimanes with antitumor and related activities until date as well as the synthesis of antitumor compounds using -halimic acid as a starting material.
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| http://dx.doi.org/10.3389/fchem.2023.1225355 | DOI Listing |
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