AI Article Synopsis
- A new method to build 2-pyrrolin-5-one was created using a simple one-pot reaction combining β-keto nitriles/esters and α-halohydroxamates.
- This process operates under mild conditions, is easy to manage, can work with a variety of starting materials, and produces good yields.
- Additionally, the resulting products can be transformed into other valuable compounds with potential biological activity, showcasing their versatile use in synthesis.
Article Abstract
A concise approach to the construction of the 2-pyrrolin-5-one scaffold was developed a one-pot reaction with formal [3 + 2] annulation/elimination between β-keto nitrile/β-keto ester and unsubstituted α-halohydroxamates. This reaction features mild conditions, easy handling, broad substrate scope and good yields. Remarkably, the products could be readily converted into potentially bioactive alkylidenepyrrolinones, pyrroles, pyran-fused pyrrole heterocycles and other useful compounds, exhibiting versatile synthetic potential.
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| http://dx.doi.org/10.1039/d3ob01140b | DOI Listing |
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