AI Article Synopsis
- * Four venom samples from a single snake were analyzed to assess shifts in protein profiles, lethality, and specific enzyme activities from 2015 to 2021.
- * Results showed that the snake's venom transitioned from being rich in myotoxins to containing more phospholipase A and metalloproteinase, with increased enzyme activity but decreased overall lethality as the snake aged.
Article Abstract
To corroborate the ontogenetic shift in the venom composition of the Mexican Black-tailed Rattlesnake (Crotalus molossus nigrescens) previously reported through the census approach, we evaluated the shift in the protein profile, lethality, and proteolytic and phospholipase activities of four venom samples obtained in 2015, 2018, 2019, and 2021 from one C. m. nigrescens individual (CMN06) collected in Durango, Mexico. We demonstrated that the venom of C. m. nigrescens changed from a myotoxin-rich venom to a phospholipase A and snake venom metalloproteinase-rich venom. Additionally, the proteolytic and phospholipase activities increased with age, but the lethality decreased approximately three times.
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| http://dx.doi.org/10.1016/j.toxicon.2023.107280 | DOI Listing |
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