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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">37673143</PMID><DateCompleted><Year>2023</Year><Month>11</Month><Day>24</Day></DateCompleted><DateRevised><Year>2023</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0003</ISSN><JournalIssue CitedMedium="Internet"><Volume>253</Volume><Issue>Pt 1</Issue><PubDate><Year>2023</Year><Month>Dec</Month><Day>31</Day></PubDate></JournalIssue><Title>International journal of biological macromolecules</Title><ISOAbbreviation>Int J Biol Macromol</ISOAbbreviation></Journal><ArticleTitle>In vitro-in vivo wound healing efficacy of Tridax Procumbens extract loaded Carboxymethylcellulose film.</ArticleTitle><Pagination><StartPage>126695</StartPage><MedlinePgn>126695</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijbiomac.2023.126695</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0141-8130(23)03592-4</ELocationID><Abstract><AbstractText>In this work, Tridax Procumbens Extracts (TPE) were blended with Carboxymethylcellulose (CMC), and film was developed through the casting method. The phytochemical screening of the TPE/CMC film was carried out and found the presence of carbohydrates, tannins, saponins, and cardiac glycosides. The presence of elements such as C, O, Na, P, Cl, K, Ca, Mn, and Nb in TP/CMC film was confirmed through EDX. The melting point of the film was found around 291&#xa0;&#xb1;&#xa0;0.5&#xa0;&#xb0;C which was determined through the DSC curve. The maximum tensile strength of the TPE/CMC was found as 14&#xa0;&#xb1;&#xa0;0.5&#xa0;MPa. The film showed antibacterial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus, and Vibrio cholera compared to the control. Cell viability study exhibited 95&#xa0;% and 98&#xa0;% cell proliferation for the test film after interacting with the L929 cell line for 18&#xa0;h and 24&#xa0;h. The optical contact angle of the TPE/CMC film was also determined. The in-vivo, wound healing studies on adult mice showed healing within 10&#xa0;days only and the histopathological results revealed the maximum number of fibroblasts with a high density of collagen fibers in the test group indicating that the prepared film can be an effective wound dressing material.</AbstractText><CopyrightInformation>Copyright &#xa9; 2023. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chinnappan</LastName><ForeName>Balaji Ayyanar</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Coimbatore Institute of Technology, Coimbatore, Tamilnadu 641014, India. Electronic address: balajiayyanar2007@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krishnaswamy</LastName><ForeName>Marimuthu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Coimbatore Institute of Technology, Coimbatore, Tamilnadu 641014, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bal</LastName><ForeName>Trishna</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences &amp; Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajora</LastName><ForeName>Aditya Dev</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences &amp; Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2023</Year><Month>09</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Biol Macromol</MedlineTA><NlmUniqueID>7909578</NlmUniqueID><ISSNLinking>0141-8130</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>K679OBS311</RegistryNumber><NameOfSubstance UI="D002266">Carboxymethylcellulose Sodium</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013634">Tannins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002266" MajorTopicYN="Y">Carboxymethylcellulose Sodium</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014945" MajorTopicYN="Y">Wound Healing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013634" MajorTopicYN="N">Tannins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antibacterial</Keyword><Keyword MajorTopicYN="N">CMC</Keyword><Keyword MajorTopicYN="N">Cytocompatibility</Keyword><Keyword MajorTopicYN="N">In-vivo wound healing</Keyword><Keyword MajorTopicYN="N">TPE</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2023</Year><Month>4</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2023</Year><Month>8</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2023</Year><Month>9</Month><Day>2</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2023</Year><Month>11</Month><Day>24</Day><Hour>6</Hour><Minute>43</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2023</Year><Month>9</Month><Day>7</Day><Hour>0</Hour><Minute>41</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2023</Year><Month>9</Month><Day>6</Day><Hour>19</Hour><Minute>23</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">37673143</ArticleId><ArticleId IdType="doi">10.1016/j.ijbiomac.2023.126695</ArticleId><ArticleId IdType="pii">S0141-8130(23)03592-4</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>