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Low-grade endometrial endometrioid carcinoma of the p53-abnormal group: case presentation and diagnostic issues.
Pathologica
October 2024
Pathology Unit, Department of Oncology, ASST Sette Laghi, Varese, Italy.
P53-abnormal endometrial carcinomas are high-grade and aggressive tumors which should be treated with chemo-/radiotherapy. In low-grade endometrioid carcinoma (LGEC), abnormal expression of p53 is an exceptional finding and is typically accompanied by patchy p16 positivity and diffuse hormone receptor expression. Herein, we report a case of LGEC exhibiting both p53 and p16 overexpression, highlighting the diagnostic pitfalls related to such phenotype.
View Article and Find Full Text PDFCharacterization of gastric/gastrointestinal-like immunophenotypes in endometrial endometrioid adenocarcinomas, including endometrioid adenocarcinomas with mucinous differentiation.
Hum Pathol
December 2024
Department of Pathology, University of California San Diego, San Diego, CA, USA. Electronic address:
Endometrial mucinous carcinoma of the gastric [gastrointestinal] type (MCG) is a rare, possibly aggressive subtype of endometrial cancer that should be distinguished from its potential mimics, including endometrioid carcinoma (EEC). Herein, we assess the frequency of gastric and gastrointestinal immunophenotypes in EEC without any discernible gastric/gastrointestinal-type morphology. Immunohistochemical analyses for KRT(CK)7, KRT20, CDX2, ER, SATB2, MUC6, PAX8, and HIK1083 were performed on 81 EEC, inclusive of consecutively archived low grade [with (n = 22) and without (n = 47) mucinous differentiation] and high grade (n = 12) cases.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the challenges of diagnosing and managing cervical lesions in patients with Peutz-Jeghers syndrome (PJS) by analyzing MRI features in relation to pathological types.
- A total of 34 PJS patients were categorized into four groups based on their lesions, revealing significant differences in MRI characteristics, such as lesion extent and microcyst distribution.
- A new grading system was developed from these MRI findings to help assess the potential malignancy of cervical lesions, aiming to improve treatment recommendations and enhance collaboration between healthcare professionals.
The Utility and Feasibility of Laparoscopic Surgery in Patients Diagnosed With Cervical Cystic Lesions.
Cureus
July 2024
Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, JPN.
Introduction: This observation study aimed to differentiate between lobular endocervical glandular hyperplasia (LEGH) and gastric-type mucinous carcinoma (GAS) while evaluating the feasibility and efficacy of laparoscopic surgery in the preoperative diagnosis of cervical cystic lesions.
Method And Material: A retrospective study was conducted to evaluate the diagnostic process and laparoscopic surgical management of cervical cystic lesions suspected to be LEGH or GAS. Preoperatively and postoperatively, MRI, cytology, histology, tumor marker analysis, and surgical outcomes (blood loss during surgery, operative time) were assessed.
[Clinicopathological features and prognostic analysis of synchronous mucinous metaplasia and neoplasia of the female genital tract].
Zhonghua Zhong Liu Za Zhi
December 2024
Department of Gynecological Oncology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai200090, China.
Article Synopsis
- Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) is a rare condition studied in 25 cases at Fudan University, focusing on its clinicopathologic characteristics and prognosis from January 2012 to October 2022.
- Most patients were around 46-47 years old, presenting symptoms like irregular vaginal bleeding, pelvic pain, and ovarian cysts; two cases were linked to Peutz-Jeghers syndrome.
- The study found that the cervix was the most affected site, with treatment often involving surgery and sometimes additional therapies, revealing that prognosis was generally good, especially when correlated with factors like disease stage and number of affected sites.
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