The crucial role of spacer ligands in affecting the contact properties of metal-2D perovskite junctions, which can severely affect device performance, is revealed in this work. We studied the contact properties of Ag, Au, and Pt with 2D perovskites that possess ligands with different sizes and functional groups. It is found that the interface binding energy, Schottky barrier height (SBH), and tunneling property depend strongly on the ligand size and functional group type. Small-size ligands can induce effective interface coupling and result in perturbed perovskite electronic properties and a high tunneling probability. In addition, high work-function metals and more electronegative functional groups can induce more severe band shifts at the interface. The features of diverse ligands ensure a widely tunable SBH ranging from 0-1.07 eV. This study provides guidance for developing more effective 2D perovskite-based electric nanodevices by tuning the contact properties through molecular engineering of spacer ligands.
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http://dx.doi.org/10.1039/d3nr02289g | DOI Listing |
Bioconjug Chem
December 2024
Department of Chemistry "Ugo Schiff" (DICUS), University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, FI 50019, Italy.
The present study reports the preparation of the first multivalent iminosugars built onto a glyco-gold nanoparticle core (glyco-AuNPs) capable of stabilizing or enhancing the activity of the lysosomal enzyme GCase, which is defective in Gaucher disease. An -nonyltrihydroxypiperidine was selected as the bioactive iminosugar unit and further functionalized, via copper-catalyzed alkyne-azide cycloaddition, with a thiol-ending linker that allowed the conjugation to the gold core. These bioactive ligands were obtained with either a linear monomeric or dendritic trimeric arrangement of the iminosugar.
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December 2024
Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, Aarhus C 8000, Denmark.
Multivalency as an interaction principle is widely utilized in nature. It enables specific and strong binding by multiple weak interactions through enhanced avidity and is a core process in immune recognition and cellular signaling, which is also a current concept in drug design. Here, we use the high signals from plasmon-enhanced fluorescence of nanoparticles to extract binding kinetics and dynamics of multivalent interactions on the single-molecule level and in real time.
View Article and Find Full Text PDFACS Nano
December 2024
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China.
ACS Omega
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, The German University in Cairo, New Cairo City, Cairo 11835, Egypt.
Drug conjugates of tamoxifen and melatonin linked through the amide side chain of melatonin (,) were reported as promising agents for future treatment of breast cancer, possibly reversing the adverse effects of tamoxifen. Here, we report the synthesis and pharmacological evaluation of a novel series of anticancer drug conjugates linking melatonin with tamoxifen through polymethylene spacers through the ether oxygen of melatonin (-, -, ) and compare them to the previously reported amide-linked analogues and . All hybrid ligands are antagonists of estrogen receptor alpha and agonists of the melatonin MT receptor with variable potencies.
View Article and Find Full Text PDFPhys Chem Chem Phys
December 2024
Kazan Federal University, Kremlevskaya 18 str, Kazan 420008, Russian Federation.
The rational design of organic ligands with the aim to control their binding abilities towards different metal ions can be considered as one of the key concepts in supramolecular coordination chemistry. Regarding the macrocyclic compounds of thiacalix[4]arene family, this can be achieved the targeted modulation of macrocyclic platform rigidity as well as the proper choice of appended binding sites. Four macrocyclic salen-type ligands based on lower rim disubstituted thiacalix[4]arene derivatives, adopted in a cone conformation, bearing highly coordinating iminophenolic or catecholic groups and two -CH- moieties as spacers but presenting different abilities to form H-bonds, were chosen to elucidate the interplay between the conformational flexibility of the macrocyclic ligands, propensity to participate in the intermolecular H-bonding and the extraction ability of 3d-metal cations.
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