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Use of Radiation Therapy for Ataxia-Telangiectasia Mutated (ATM)-Mutation Metastatic Renal Cell Carcinoma: A Case Report.
Cureus
July 2024
Hematology and Oncology, University of California Irvine Medical Center, Orange, USA.
Article Synopsis
- Papillary renal cell carcinoma (pRCC) is a rare and challenging form of kidney cancer with limited treatment options and poor prognosis, especially when it spreads.
- A 42-year-old male with metastatic pRCC, who had a specific genetic mutation (ATM), underwent various treatments, including immunotherapy and radiation, but faced issues with side effects and disease progression.
- Remarkably, even after a 10-month treatment hiatus, the patient's condition remained stable, suggesting that the ATM mutation may have made his cancer more responsive to radiation therapy.
Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer.
Front Med
August 2024
Department of Gastroenterology and Hepatology, the First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Synthetic lethality is a novel model for cancer therapy. To understand the function and mechanism of BEN domain-containing protein 4 (BEND4) in pancreatic cancer, eight cell lines and a total of 492 cases of pancreatic neoplasia samples were included in this study. Methylation-specific polymerase chain reaction, CRISPR/Cas9, immunoprecipitation assay, comet assay, and xenograft mouse model were used.
View Article and Find Full Text PDFTargeted sequencing of DNA/RNA combined with radiomics predicts lymph node metastasis of papillary thyroid carcinoma.
Cancer Imaging
June 2024
Cancer Molecular Diagnostics Core, Key Laboratory of Cancer Immunology and Biotherapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
Objective: The aim of our study is to find a better way to identify a group of papillary thyroid carcinoma (PTC) with more aggressive behaviors and to provide a prediction model for lymph node metastasis to assist in clinic practice.
Methods: Targeted sequencing of DNA/RNA was used to detect genetic alterations. Gene expression level was measured by quantitative real-time PCR, western blotting or immunohistochemistry.
Somatic loss of ATM is a late event in pancreatic tumorigenesis.
J Pathol
August 2023
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Article Synopsis
- * Researchers analyzed DNA from invasive pancreatic adenocarcinomas and precursor lesions of patients with and without ATM genetic variants to assess how these alterations contribute to cancer development.
- * Findings revealed that somatic ATM alterations were present in a significant majority of invasive cancers (75%) but were much less common in precursor lesions (7.1%), suggesting that alterations may occur later in the progression of pancreatic cancer.*
Pancreatic Cancer Screening for At-Risk Individuals (Pancreas Scan Study): Yield, Harms, and Outcomes From a Prospective Multicenter Study.
Am J Gastroenterol
September 2023
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts, USA.
Introduction: Guidelines endorse pancreatic cancer screening in genetically susceptible individuals. We conducted a prospective, multicenter study to determine yield, harms, and outcomes of pancreatic cancer screening.
Methods: All high-risk individuals undergoing pancreatic cancer screening at 5 centers from 2020 to 2022 were prospectively enrolled.
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