AI Article Synopsis
- Antimicrobial resistance is a growing global health issue, prompting research into new materials to fight multi-drug-resistant bacteria.
- This study introduces surfactin-coated silver nanoparticles, demonstrating their effectiveness as an antibacterial and antibiofilm agent with safe dermal applications.
- Results indicate that these nanoparticles do not cause significant skin irritation or pathological changes, supporting their potential for treating drug-resistant bacterial infections and improving wound care.
Article Abstract
The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and antibiofilm agent against the drug-resistant bacteria for safe dermal applications. Our studies showed no significant superficial dermal irritation, edema, and erythema, while microscopic analysis revealed that surfactin-coated silver nanoparticles caused no pathological alterations at the applied concentrations. These results support the potential use of surfactin-coated silver nanoparticles against drug-resistant bacterial biofilm infections and in skin wound dressing applications.
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| http://dx.doi.org/10.1021/acsami.3c07071 | DOI Listing |
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