AI Article Synopsis
- Cigarette smoking is linked to multiple serious diseases, and effective methods for helping smokers quit are crucial for public health.
- Current smoking cessation therapies, like nicotine replacement and varenicline, have limitations and high costs, highlighting the need for better screening approaches.
- A study investigating DNA methylation in smokers found no significant differences in the SHATI/NAT8L gene, indicating that further research is needed to identify reliable biomarkers for smoking cessation effectiveness.
Article Abstract
Aims: Cigarette smoking is a preventable risk factor for various diseases such as cancer, ischemic stroke, cardiac stroke, and chronic obstructive pulmonary disease. Smoking cessation is of great importance not only for individual smokers but also for social health. Regarding current cessation therapies, the effectiveness of nicotine replacement is limited, and the cost of varenicline medication is considerable. Thus, a method for screening smokers who are responsive to cessation therapy based on the therapeutic effectiveness is required. Peripheral biomarkers reflecting smoking dependence status are necessary to establish a method for achieving effective cessation therapy.
Methods: Methylation status of smokers' blood DNA was evaluated focusing on SHATI/NAT8L, an addiction-related gene. Eight CpG sites in SHATI/NAT8L were quantified by pyrosequencing.
Results: There was no difference in the methylation status of this gene between smokers (n = 129) and non-smokers (n = 129) at all CpG sites. No correlations between the methylation status of SHATI/NAT8L and indicators of smoking dependence were found.
Conclusions: Although the present study found no significance in the DNA methylation of SHATI/NAT8L among smokers, the exploration of predictable peripheral biomarkers for the effectiveness of smoking cessation therapy is required.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739067 | PMC |
| http://dx.doi.org/10.1002/npr2.12373 | DOI Listing |
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