AI Article Synopsis
- Allergy affects roughly 20% of the global population, and there's growing interest in natural remedies like stingless bee honey (Kelulut honey or KH) as alternatives to conventional treatments, particularly in Malaysia where it's traditionally used for cough and asthma relief.
- This study tested the ability of KH from different sources (bamboo, rubber tree, mango, and noni) to reduce the release of inflammatory mediators in human mast cells, with bamboo and rubber tree honey showing significant inhibitory effects.
- Results highlighted that bamboo and rubber tree honey had higher total phenolic content and rich phytochemical profiles, suggesting their anti-allergic properties may work by targeting specific signaling pathways in activated mast cells.
Article Abstract
Background: Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells.
Methods: The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC-MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods.
Results: The results indicated that there were significant inhibitory effects on all selected inflammatory mediators' release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC-MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers.
Conclusions: In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10476411 | PMC |
| http://dx.doi.org/10.1186/s12906-023-04129-y | DOI Listing |
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