AI Article Synopsis

  • Biological treatments are becoming vital for managing moderate-to-severe atopic dermatitis in children, with dupilumab and tralokinumab currently approved for use.
  • Dupilumab has recently been extended for pediatric patients as young as six months, but details on its practical use for infants and young children are limited.
  • There are ongoing concerns about the long-term effects and specific implementation challenges of biologicals in infants and preschoolers, highlighting a need for more research in this area.

Article Abstract

Biologicals are becoming increasingly important in the therapeutic landscape of pediatric patients with moderate-to-severe atopic dermatitis (AD). Currently, dupilumab and tralokinumab are registered for the treatment of moderate-to-severe AD, and novel biologicals are expected to follow. Dupilumab was the first biological registered for AD in pediatric patients and was recently approved for patients aged six months to five years. Current and emerging biologicals may address the unmet need for effective and safe treatment options for pediatric AD patients, however, little is known about the practical implementation of biologicals in infants and preschoolers (aged <6 years), including the timing of treatment initiation, discontinuation, and long-term administration of the subcutaneous injections. Currently, only a small number of biologicals are approved for the treatment of infants and preschoolers for other inflammatory diseases. Consequently, data on the practical implementation of biological treatment remain scarce. In addition, long-term effects, impact on co-morbidities, and impact on live-accentuated vaccination are still unknown. With the introduction of biologicals for AD from the age of six months, potential challenges within the implementation of biologicals may arise. Therefore, we aim to discuss current practical challenges and knowledge gaps of the treatment with biologicals in infants and preschoolers with AD.

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Source
http://dx.doi.org/10.1080/09546634.2023.2254567DOI Listing

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