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LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3. | LitMetric

LncRNA TYMSOS facilitates breast cancer metastasis and immune escape through downregulating ULBP3.

iScience

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China.

Published: September 2023

The focus of the study is to examine the function of TYMSOS in immune escape of breast cancer, which is the most frequently diagnosed malignancy among women globally. Our study demonstrated that upregulated TYMSOS was associated with unfavorable prognosis and immune escape in breast cancer. TYMSOS promoted the malignant phenotypes of breast cancer cells, and reduced the cytotoxicity of NK92 cells on these cells. CBX3 was a downstream effector in TYMSOS-induced malignant phenotypes in breast cancer cells. Mechanistic studies showed that TYMSOS facilitated CBX3-mediated transcriptional repression of ULBP3, and it also promoted SYVN1-mediated ubiquitin-proteasomal degradation of ULBP3. TYMSOS promoted cell growth, metastasis, and immune escape via CBX3/ULBP3 or SYVN1/ULBP3 axis. The studies further showed that silencing of TYMSOS repressed tumor growth and boosted NK cell cytotoxicity. In sum, TYMSOS boosted breast cancer metastasis and immune escape via CBX3/ULBP3 or SYVN1/ULBP3 axis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470366PMC
http://dx.doi.org/10.1016/j.isci.2023.107556DOI Listing

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