AI Article Synopsis
- - Rotator cuff tendinopathy is a widespread and costly musculoskeletal disorder, with stem cell therapy showing promise for healing in advanced cases, although it's not yet widely approved for use.
- - Clinical trials suggest stem cell therapy could be effective for treating this condition, but significant challenges remain, including determining the best stem cell sources and dosages.
- - The article discusses strategies for standardizing stem cell populations and selecting appropriate patients, aiming to enhance the clinical application of this innovative treatment.
Article Abstract
Unlabelled: Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy for rotator cuff tendinopathy, but its application has not been promoted and approved. There are still many issues that should be solved prior to using stem cell therapy in clinical applications. The optimal source and dose of stem cells for rotator cuff tendinopathy should be determined. We also proposed novel prospective approaches that can overcome cell population heterogeneity and standardize patient types for stem cell applications.
The Translational Potential Of This Article: This review explores the optimal sources of stem cells for rotator cuff tendinopathy and the principles for selecting stem cell dosages. Key strategies are provided for stem cell population standardization and recipient selection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470406 | PMC |
| http://dx.doi.org/10.1016/j.jot.2023.07.006 | DOI Listing |
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