Synthesis of an aggregation-induced emission-based fluorescent probe based on rupestonic acid.

RSC Adv

College of Chemistry and Environmental Science, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashi University Kashi 844000 China +86-18690293325.

Published: August 2023

AI Article Synopsis

  • Chinese herbal and patent medicines are commonly used in cancer treatment in China.
  • Rupestonic acid, an active component of a specific herbal plant, has shown potential anti-tumor effects recently.
  • A study developed a fluorescent probe using rupestonic acid integrated into an AIE system, demonstrating promising anti-tumor properties that could be useful for cancer diagnosis and treatment.

Article Abstract

Chinese herbal medicine and Chinese patent medicine have been widely applied for cancer care in China. Rupestonic acid, an active ingredient of L., has recently been confirmed to have certain anti-tumor effects . In this study, we employed the application of a commonly devoted triphenylamine as a fluorophore and the addition of 2,4-thiazolidinedione as a bridge to integrate rupestonic acid into the AIE system to create an fluorescent probe with anti-tumor properties. The spectral, cytotoxic, and cellular imaging properties of the probe were measured. Its promising responses make possible the application of the probe in antitumor theragnostic systems.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10472508PMC
http://dx.doi.org/10.1039/d3ra03521bDOI Listing

Publication Analysis

Top Keywords

rupestonic acid
12
fluorescent probe
8
synthesis aggregation-induced
4
aggregation-induced emission-based
4
emission-based fluorescent
4
probe
4
probe based
4
based rupestonic
4
acid chinese
4
chinese herbal
4

Similar Publications

Hepatitis B surface antigen (HBsAg) is not only the biomarker of hepatitis B virus (HBV) infection and expression activity in hepatocytes, but it also contributes to viral specific T cell exhaustion and HBV persistent infection. Therefore, anti-HBV therapies targeting HBsAg to achieve HBsAg loss are key approaches for an HBV functional cure. In this study, we found that YZH-106, a rupestonic acid derivative, inhibited HBsAg secretion and viral replication.

View Article and Find Full Text PDF

Bioactive compounds from dichloromethane extract of Artemisia rupestris L. alleviates CCl/ConA-induced acute liver injury by inhibiting PI3K-AKT pathway.

J Ethnopharmacol

October 2024

School of Pharmacy/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education/School of Medicine, Shihezi University, Shihezi, 832003, China. Electronic address:

Ethnopharmacological Relevance: Artemisia rupestris L. (AR) is a traditional medicinal herb commonly used in the Uyghurs and Kazakhs; it was first documented in the Supplement to Compendium of Materia Medica written by Zhao Xuemin in the Qing Dynasty of China and is used clinically to treat colds, hepatitis, and allergic diseases.

Aim Of The Study: The material basis and mechanisms of AR in acute liver injury (ALI) remain unclear.

View Article and Find Full Text PDF

Background: Influenza virus is a kind of RNA virus. Nowadays, the high incidence of influenza and the morbidity and mortality of epidemic influenza are substantial. It has been reported that one hundred million people in the world are infected with influenza viruses, and two hundred and fifty thousand to five hundred thousand people die from the flu per year.

View Article and Find Full Text PDF

Synthesis of an aggregation-induced emission-based fluorescent probe based on rupestonic acid.

RSC Adv

August 2023

College of Chemistry and Environmental Science, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashi University Kashi 844000 China +86-18690293325.

Article Synopsis
  • Chinese herbal and patent medicines are commonly used in cancer treatment in China.
  • Rupestonic acid, an active component of a specific herbal plant, has shown potential anti-tumor effects recently.
  • A study developed a fluorescent probe using rupestonic acid integrated into an AIE system, demonstrating promising anti-tumor properties that could be useful for cancer diagnosis and treatment.
View Article and Find Full Text PDF

Pharmacokinetic Study and Metabolite Identification of CAM106 in Rats by Validated UHPLC-MS/MS.

Pharmaceuticals (Basel)

May 2023

State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

Given the limitations of existing antiviral drugs and vaccines, there is still an urgent need for new anti-influenza drugs. CAM106, a rupestonic acid derivative, was studied for its potent antiviral activity and showed a favorable inhibitory effect on influenza virus replication. However, many gaps exist in preclinical studies of CAM106.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!