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The Potential of Neonatal Organ Donation in Central Sweden.
Cell Transplant
January 2025
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Pediatric organ transplant recipients have a higher risk for wait list mortality due to the scarcity of size matched organs. Neonatal organ donation could potentially ameliorate the discrepancy but is currently not implemented in Sweden. This study aims to evaluate the potential of neonatal organ donation in central Sweden using a standardized protocol with organ specific criteria.
View Article and Find Full Text PDFNew Onset of Systolic Anterior Motion and Severe Mitral Regurgitation after Warm Ischemia in Donation after Circulatory Death Heart Transplantation.
Ann Card Anaesth
January 2025
Department of Anesthesiology, IDIBAPS, Hospital Clínic, University of Barcelona, 10 Villarroel St, Barcelona, Spain.
Donation after circulatory death is helping to expand the donor pool for heart transplantation. Nevertheless, these hearts are more susceptible to myocardial edema and decision of accepting the organ can be a challenge for the heart transplant team. Hemodynamic and echocardiographic criteria are used routinely, but there is still a lack of strong evidence that supports the decision-making in particular situations.
View Article and Find Full Text PDFRepurposing the prostaglandin analogue treprostinil and the calcium-sensing receptor modulator cinacalcet to revive cord blood as an alternate source of hematopoietic stem and progenitor cells for transplantation.
Front Pharmacol
January 2025
Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Objective: The expanding field of hematopoietic cell transplantation (HCT) for non-malignant diseases, including those amenable to gene therapy or gene editing, faces challenges due to limited donor availability and the toxicity associated with cell collection methods. Umbilical cord blood (CB) represents a readily accessible source of hematopoietic stem and progenitor cells (HSPCs); however, the cell dose obtainable from a single cord blood unit is frequently insufficient. This limitation can be addressed by enhancing the potency of HSPCs, specifically their capacity to reconstitute hematopoiesis.
View Article and Find Full Text PDFFactors related to milk donation based on the theory of planned behavior in pregnant women.
Sci Rep
January 2025
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
The willingness to donate milk is influenced by maternal behavior, and the Theory of Planned Behavior is recognized as a significant predictor of this action. This study aims to identify the factors associated with milk donation among pregnant women based on the Theory of Planned Behavior. This descriptive and analytical cross-sectional study utilized stratified and convenience sampling methods on 337 pregnant women attending women's health and midwifery clinics affiliated with Mashhad University of Medical Sciences in 2024.
View Article and Find Full Text PDFOnly IF/TA in the Histological Evaluation of Post-Reperfusion Baseline Biopsies Correlates With Kidney Transplant Outcome.
Transpl Int
January 2025
Department of Nephrology, University Hospital Rechts der Isar, Technical University of Munich, TUM School of Medicine and Health, Munich, Germany.
Here, we retrospectively evaluated the informational yield of 338 post-reperfusion kidney transplant biopsies (including 95 living donations) assessed according to BANFF for the histological characteristics interstitial fibrosis and tubular atrophy (IF/TA), glomerulosclerosis, arteriosclerosis, and acute tubular injury (ATI). Associations with delayed graft function (DGF) and death-censored graft survival were explored through Cox-regression analyses. The maximum follow-up time was 11.
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