AI Article Synopsis

  • A study found that a high percentage (83.16%) of ICU COVID-19 patients experienced healthcare-associated infections (HAIs), mostly caused by bacteria like Klebsiella pneumoniae and Acinetobacter baumannii.
  • Significant mortality and intubation rates were linked to these superinfections, with specific predictors identified, highlighting the critical role of antibiotic management.
  • The research underscored the urgency for tailored antibiotic treatment strategies and improved infection control practices in healthcare settings to combat these resistant infections.

Article Abstract

Background: The emergence of healthcare-associated infections (HAIs) or superinfections in COVID-19 patients has resulted in poor prognosis and increased mortality.

Methods: In a cross-sectional study, 101 respiratory samples were collected from ICU-admitted COVID-19 patients. The HAI rate, demographics, and antibiotic resistance were assessed.

Results: The HAI rate was 83.16% (76.62% bacterial and 6.54% fungal). The prevalence of 3 major HAI-causing organisms included Klebsiella pneumoniae (41.5%), Acinetobacter baumannii (20.8%), and Staphylococcus aureus (4.9%). Mortality and intubation ventilation proportions of 90% (p = 0.027) and 92.2% (p = 0.02) were significant among patients with superinfection, respectively. Multiple logistic regression analysis showed SpO pressure (odds ratio 0.842; 95% CI 0.750-0.945; p = 0.004) as a predictive factor in the association between antibiotic usage and mortality. More than 50% of patients received carbapenems. The resistance rates to at least one antibiotic of third-generation cephalosporins, aminoglycosides, quinolones/fluoroquinolones, tetracyclines, and β-lactam inhibitors were 95.2%, 95.2%, 90%, 57.1%, and 100% among A. baumannii isolates and 71.4%, 55%, 69%, 61.9%, and 59.5% among K. pneumoniae isolates, respectively. A proportion of 60% was recorded for methicillin-resistant S. aureus isolates.

Conclusion: As a result, antibiotic treatment should be administered following the microbial resistance profile. Contact isolation and infection control measures should be implemented as needed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10474718PMC
http://dx.doi.org/10.1186/s40001-023-01303-3DOI Listing

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