Rationale: Cranioplasty after decompressive craniectomy provides brain protection and improves cerebral hemodynamics. However, recurrent infection and sinking skin flap syndrome after cranioplasty remain cumbersome complications that require a well-planned reconstruction strategy.
Patient Concerns: A 74-year-old man presented with traumatic subdural hematoma and underwent decompressive craniectomy. Cranioplasty using an original bone flap, bone cement with wires, and a titanium mesh were complicated and resulted in recalcitrant infection and sinking skin flap syndrome.
Diagnoses: Recurrent infection and sinking skin flap syndrome post-cranioplasty.
Interventions: We designed a two-stage "kebab" reconstruction technique using a combination of free latissimus dorsi myocutaneous flap and delayed non-vascularized free rib graft. A well-vascularized musculocutaneous flap can obliterate dead space in skull defects and reduce bacterial inoculation in deep infections. Subsequently, delayed rib grafts act as the scaffold to expand the sunken scalp flap.
Outcomes: At the 3-year follow-up, the patient showed improvement in headache, without evidence of surgical site infection.
Lessons: The novel "kebab" technique using a combination of a free myocutaneous flap and delayed rib graft can eliminate bacterial growth in infected calvarial defects, reverse sinking skin flap syndrome, and minimize potential donor-site morbidity, and is therefore suitable for patients who require multiple cranioplasties and are unable to withstand major reconstructions.
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http://dx.doi.org/10.1097/MD.0000000000034963 | DOI Listing |
Neurol Res
January 2025
Department of Neurosurgery, The First Hospital of Lanzhou University, Lanzhou, China.
Sinking Skin Flap Syndrome(SSFS) is a rare and specific complication following decompressive craniectomy(DC). Another condition, known as syndrome of the trephined(ST), shares many similarities in clinical symptoms and signs with this condition, yet they are fundamentally different. Therefore, they should be considered as two distinct diseases, and their respective concepts should not be used interchangeably as synonyms.
View Article and Find Full Text PDFJ Med Case Rep
December 2024
Department of Neurology, Los Angeles General Medical Center/University of Southern California, 1100 N. State St., Clinic Tower A4E, Los Angeles, CA, 90034, USA.
Background: The sunken flap or sinking skin flap syndrome is a complication that can be observed following decompressive craniectomy. More rare, sinking skin flap syndrome can occur as an iatrogenic complication of pleural effusion evacuation via chest tube placement in the presence of ventriculopleural shunt.
Case Presentation: We report the case of a Hispanic male patient in his 20s who presented to the emergency department after sustaining a penetrating gunshot wound to the head.
Br J Oral Maxillofac Surg
December 2024
Resident Oral and Maxillofacial Surgery, Division of Oral and Maxillofacial Surgery, AFMC, Pune, India. Electronic address:
Cranioplasty performed after a decompressive craniectomy (DC) for traumatic brain injury (TBI), stroke, or aneurysmal bleed has a role of restoring cerebral protection and craniofacial cosmesis as well as improving neuromotor function. There has been no consensus with regards to the ideal timing of cranioplasty (CP) after DC. A retrospective cohort study was carried out at a tertiary care hospital on patients who had undergone early (less than or equal to 12 weeks) and late (greater than 12 weeks) cranioplasty using autologous cranial bone after DC.
View Article and Find Full Text PDFFront Toxicol
September 2024
Neurology, Environmental and Occupational Medicine Associates, CA and Division of Medicine, Occupational Medicine, University of California at San Francisco, San Francisco, CA, United States.
There is a well-recognized relationship between a person's body burden of essential trace elements such as copper and their neurological function in which both deficiencies and exposures to excessive concentrations are associated with adverse clinical outcomes. Preclinical studies indicate chronic excess copper exposure is associated with altered motor function, dopaminergic neuronal loss, astrocytosis, and microgliosis. Copper also promotes oligomerization and fibrilization of α-synuclein suggesting it may hasten the course of an α-synucleinopathy.
View Article and Find Full Text PDFCurr Pharm Biotechnol
May 2024
Division of pharmacology, Institute of Pharmaceutical Research, GLA University, 19#Km Stone, Delhi-Mathura Highway, Chaumuhan, Mathura-281406, (U.P.) India.
Melanocytes are highly specialized dendritic cells that deliver melanin to keratinocytes in melanosomes, which are subcellular organelles where melanin is produced and stored. Mammal's skin, hair, and eyes all contain the complex pigment melanin, which gives them color and ultraviolet protection. Melanins have the potential to be free radical sinks and are strong cation chelators.
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