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Relationship between Age-Related Hearing Loss and Age-Related Macular Degeneration.
Noise Health
January 2025
Department of Ophthalmology, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China.
Background: With the aging of the population, the deterioration of visual and auditory functions amongst the elderly has attracted much attention. Age-related hearing loss (ARHL) and age-related macular degeneration (AMD) are common eye and ear diseases that seriously affect the quality of life of elderly population.
Methods: This study utilised a whole cohort sampling method, with a total of 713 participants aged 50 years and older in the community from June 2022 to October 2023, resulting in the inclusion of 620 participants.
Retrospective study of incidence/prevalence of pigmentary maculopathy and retinopathy in patients receiving pentosan polysulfate sodium.
PLoS One
January 2025
Verana Health, San Francisco, CA, United States of America.
Purpose: To evaluate prevalence and incidence rates of pigmentary maculopathy and retinopathy (PM/PR), and visual acuity (VA) changes in patients exposed to pentosan polysulfate sodium (PPS) and in patients with interstitial cystitis (IC) not exposed to PPS.
Methods: This is a retrospective cohort study (January 2015-March 2021) which included adult de-identified patients from the American Academy of Ophthalmology IRIS® Registry (Intelligent Research in Sight) and Komodo Health database. Three patient cohorts were identified: two PPS-exposed patient cohorts, and Non-PPS-exposed IC patient cohort.
The Effects of Anti-Vascular Endothelial Growth Factor Loading Injections on Retinal Microvasculature in Diabetic Macular Edema.
Transl Vis Sci Technol
December 2024
Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, Korea.
Purpose: To evaluate changes in the retinal microvasculature using widefield swept-source optical coherence tomography angiography (SS-OCTA) following three anti-vascular endothelial growth factor (anti-VEGF) loading injections for diabetic macular edema (DME).
Methods: Thirty-four treatment-naïve patients with DME received an initial three loading injections, followed by injections on an as-needed basis. Macular ischemia was evaluated based on the foveal avascular zone (FAZ) area, perfusion density, and vessel density on a 3 × 3-mm SS-OCTA image.
Biomarkers.
Alzheimers Dement
December 2024
Ophthalmology, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea, Republic of (South).
Background: Spectrum Domain-Optical Coherence Tomography (SD-OCT) is a non-invasive technology that acquires cross-sectional images of retinal structures allowing neural fundus integrity assessment. Macular thickness and retinal nerve fiber layer (RNFL) thickness measured by an SD-OCT have been used as a indicator of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). However which portion of retinal RNFL is the most sensitive area among normal control, aMCI and AD is not clear yet.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Alabama at Birmingham, Birmingham, AL, USA.
Background: The potential of plasma Aβ42/Aβ40 ratio, NfL, p-tau 181, and p-tau 217 has been extensively discussed in the literature. Our previous study explored the association between retinal biomarkers and preclinical AD. The goal of this study was to evaluate the association and a multimodal model of retinal and plasma biomarkers for detection of preclinical AD.
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