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Animal models in biomedical research: Relevance of .
Heliyon
January 2025
Department of Life and Consumer Sciences, School of Agriculture and Life Sciences, University of South Africa, 1710, Johannesburg, South Africa.
Animal models have become veritable tools in gaining insight into the pathogenesis and progression of several human diseases. These models could range in complexity from to non-human primates. With the aid of these animal models, a lot of new knowledge has been gained about several diseases which otherwise would not have been possible.
View Article and Find Full Text PDFNon-targeted metabonomics reveals the effect of linalyl alcohol on Brochothrix thermophile and its potential application.
Food Res Int
February 2025
College of Food Sciences & Engineering, Hainan University, 58 People Road, Haikou 570228, China. Electronic address:
Brochothrix thermophcta (B. thermophcta) is a pathogenic microorganism associated with food contamination. Linalyl alcohol, owing to its broad spectrum and exceptional antibacterial properties, is regarded as a potent natural antimicrobial agent.
View Article and Find Full Text PDFDysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms.
Biomark Res
January 2025
Department of Genomics, Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Background: Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source of genome instability leading to oncogenesis, whereas small PIWI-interacting RNAs (piRNAs) act as cellular suppressors of TEs. However, the roles of TEs and piRNAs in MDS remain unclear.
View Article and Find Full Text PDFPrevalence of chronic kidney disease in Saudi Arabia: an epidemiological population-based study.
BMC Nephrol
January 2025
Department of Clinical Pharmacy, King Khalid University, 61421, Abha, Saudi Arabia.
Background: Chronic kidney disease (CKD) is a prevalent global health issue affecting millions of patients worldwide, impacting quality of life, impeding physical and psychological well-being, causing financial stress, and increasing mortality rates. This study aimed to highlight the prevalence of CKD and its associated risk factors across Saudi Arabia.
Method: This is a cross-sectional study conducted from 2015 to 2022, using data from 42 branches of a major network of diagnostic laboratories in Saudi Arabia, covering the country's 13 administrative areas.
Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya.
BMC Genomics
January 2025
Program in Public Health, College of Health Sciences, University of California, Irvine, California, USA.
Background: The resurgence of Anopheles funestus, a dominant vector of human malaria in western Kenya was partly attributed to insecticide resistance. However, evidence on the molecular basis of pyrethroid resistance in western Kenya is limited. Here, we reported metabolic resistance mechanisms and demonstrated that multiple non-coding Ribonucleic Acids (ncRNAs) could play a potential role in An.
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