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Alternatives to Injectable Adrenaline for Treating Anaphylaxis.
Clin Exp Allergy
January 2025
Service de Pneumologie A, APHP, Hôpital Bichat, Paris, France.
Adrenaline is the first line treatment for anaphylaxis and adrenaline auto-injectors (AAI) allow reliable, safe and ergonomic administration in the community. However, AAIs have significant limitations and adrenaline is often not used in anaphylaxis. Innovations to administer adrenaline via alternative routes may potentially improve usage rates and treatment effectiveness.
View Article and Find Full Text PDFInvestigating awareness and implementation of adrenaline auto-injectors (AAI) via the 'Spare Pens in Schools' scheme in Wales: a cross-sectional pilot study.
BMJ Paediatr Open
November 2024
University of Southampton, Southampton, UK.
Objective: To investigate awareness and implementation of the Spare Pens (ie, adrenaline auto-injectors (AAIs)) scheme in primary and secondary schools in two regions in Wales.
Design: A cross-sectional pilot study employing a mixed research methods approach was carried out.
Setting And Participants: State primary and secondary schools within Swansea and Pembrokeshire regional authorities were invited to take part.
Adrenaline Auto-Injectors for Preventing Fatal Anaphylaxis.
Clin Exp Allergy
January 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Article Synopsis
- * Adrenaline is the primary treatment for anaphylaxis, with autoinjectors becoming standard care, but studies indicate that current autoinjectors may not significantly reduce fatal cases.
- * There are ongoing discussions about finding alternative methods to deliver a sustained adrenaline infusion reliably, as existing autoinjectors produce brief adrenaline spikes that may not be sufficient for effective treatment.
Time Trends, Regional Variation and Associations of Low-Allergy Formula Prescribing in England.
Clin Exp Allergy
November 2024
National Heart and Lung Institute, Imperial College London, London, UK.
Article Synopsis
- Cow's milk allergy (CMA) overdiagnosis is rising, leading to an increase in prescriptions for low-allergy formulas in England, which grew from 6.1 to 23.3 liters per birth between 2007 and 2023.
- Prescription rates for these formulas varied widely by region, ranging from 0.8 to 47.6 liters per birth from 2017-2019, with significant correlations identified between low-allergy formula prescriptions and the use of certain medications like milk feed thickeners and anti-reflux medications in children.
- Regional socio-economic factors and standard CMA guidelines showed no significant association with the rates of low-allergy formula prescribing.
To the ER? Can Patients Treat Their Anaphylaxis at Home?
Curr Allergy Asthma Rep
November 2024
Department of Allergy and Immunology, Texas Children's Hospital, Houston, TX, USA.
Purpose Of Review: To discuss if all patients who use self-injectable epinephrine outside the hospital setting require immediate emergency care.
Recent Findings: Prior to 2023, anaphylaxis management guidance universally recommended that patients who use self-injectable epinephrine outside of the hospital or clinic setting immediately activate emergency medical services and seek further care. Additional food-induced anaphylaxis management recommendations specified that all patients always carry 2 auto-injector devices and give a second dose of epinephrine if there was not immediate response within 5 min of injection.
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