Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter.

Nat Cardiovasc Res

Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Published: July 2023

Structural determination of the ABCC4 transporter is a major first step in providing crucial molecular insights into the transport of platelet substrates into granules, as well as drug transport from platelets. The findings provide a framework for understanding platelet interactions and potential design of specific platelet antagonists.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470688PMC
http://dx.doi.org/10.1038/s44161-023-00293-zDOI Listing

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