Key Clinical Message: -deficient thoracic carcinoma is a malignant tumor that may present as cancer of unknown primary. This tumor is refractory and requires a novel approach. In addition to identifying therapeutic targets, multigene panel testing can reveal novel genetic mutations, leading to more pathologically relevant diagnoses and appropriate tumor care.

Abstract: -deficient undifferentiated tumors are characterized by inactivation. We present a case of a 74-year-old man with an undifferentiated tumor and a novel mutation detected using multigene panel testing. The tumor was multiagent and refractory to three chemotherapy lines. The test results helped guide appropriate medical management.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465722PMC
http://dx.doi.org/10.1002/ccr3.7854DOI Listing

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