A Rare Case of Anaplastic Large Cell Lymphoma of the Knee Joint.

J Orthop Case Rep

Department of Pathology, Ruby Hall Clinic, Pune, Maharashtra, India.

Published: August 2023

Introduction: Anaplastic large cell lymphoma (ALCL), which makes up only 2-5% of instances of NHL, is a rare and aggressive form of the disease. Anaplastic Lymphoma Kinase (ALK)-positive ALCL is a variant of the illness that is identified by the presence of an ALK gene fusion. The disease is most commonly confined to the nodes, but extranodal spread has been reported. Skin and soft tissue are the most frequently identified locations for extranodal involvement, while joints are extremely rare. We describe a rare case of ALCL affecting the knee joint that is ALK -positive.

Case Report: A 51-year-old female presented with pain in her right knee. It was diagnosed as synovitis and treated accordingly. The symptoms did not relieve and a magnetic resonance imaging (MRI) scan was performed that indicated a meniscus tear. She was treated for it; however, the symptoms worsened. She underwent two more scans (1 MRI and 1 PET) that indicated an enhancing polypoidal mass in the knee joint, and two arthroscopic procedures. The histopathology report indicated an ALK-positive ALCL. She was treated with Brentuximab vedotin + CHP followed by involved-site radiotherapy to the postoperative region with margins. The patient has had a complete clinical and pathological response which was assessed after 1 year from the start of the treatment.

Conclusion: This is the first instance of primary ALK-positive ALCL affecting the knee joint that has been documented, to the best of our knowledge. The case emphasizes the significance of taking ALCL into account when determining the differential diagnosis of knee joint tumors as well as the requirement for a thorough assessment of extranodal involvement.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465743PMC
http://dx.doi.org/10.13107/jocr.2023.v13.i08.3806DOI Listing

Publication Analysis

Top Keywords

knee joint
20
alk-positive alcl
12
rare case
8
anaplastic large
8
large cell
8
cell lymphoma
8
extranodal involvement
8
alcl knee
8
treated symptoms
8
knee
6

Similar Publications

The meniscus plays a vital role in knee biomechanics, particularly in load distribution and stability. Meniscus root tears (MRTs) compromise these functions, resulting in biomechanical alterations and knee osteoarthritis. The effectiveness of different MRT treatments is not yet well defined.

View Article and Find Full Text PDF

Background: The goal of this study was to examine the effects of spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss of sensory feedback and alterations in gait biomechanics, including co-contractions of antagonist muscles about the knee and ankle, and reduced pelvic obliquity range-of-motion and pelvic drop. SCS can restore sensation in the missing limb, but its effects on muscle activation and gait biomechanics have not been studied in people with lower-limb amputation.

View Article and Find Full Text PDF

Background: Acupuncture is an effective treatment for knee osteoarthritis (KOA), reducing pain and improving function. While melatonin (MLT) has notable pain relief benefits, the analgesic mechanism of acupuncture in KOA and its relationship with melatonin are still unknown. This study aims to explore this mechanism.

View Article and Find Full Text PDF

The long jump is an athletic event that demands speed, power, force application, and balance, with each phase being critical to overall performance. However, previous research has neglected the limiting effect of the wedge pedals on ankle dorsiflexion range of motion. This cross-sectional study investigated biomechanical changes in the lower extremities during long jumps under varying degrees of ankle dorsiflexion.

View Article and Find Full Text PDF

Background: A contemporary trend favours a restricted kinematic alignment (rKA) strategy, incorporating safe boundaries to restore a variable percentage of a patient's natural alignment.This study aims to compare preoperative and postoperative coronal plane knee alignment (CPAK) in patients undergoing bilateral TKA with SAIPH implants (MatOrtho, UK). The concept was to control the implant (same prosthesis both sides), patient (bilateral model) and assess what effect any surgical alteration in alignment had on patient's outcomes measured by patient-reported outcome measures (PROMS) and patient satisfaction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!