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A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina.
Nat Commun
January 2025
Center for Synaptic Neuroscience, Istituto Italiano di Tecnologia, Genova, Italy.
The lack of effective therapies for visual restoration in Retinitis pigmentosa and macular degeneration has led to the development of new strategies, such as optogenetics and retinal prostheses. However, visual restoration is poor due to the massive light-evoked activation of retinal neurons, regardless of the segregation of visual information in ON and OFF channels, which is essential for contrast sensitivity and spatial resolution. Here, we show that Ziapin2, a membrane photoswitch that modulates neuronal capacitance and excitability in a light-dependent manner, is capable of reinstating, in mouse and rat genetic models of photoreceptor degeneration, brisk and sluggish ON, OFF, and ON-OFF responses in retinal ganglion cells evoked by full-field stimuli, with reactivation of their excitatory and inhibitory conductances.
View Article and Find Full Text PDFA Bibliometric Review of Brain-Computer Interfaces in Motor Imagery and Steady-State Visually Evoked Potentials for Applications in Rehabilitation and Robotics.
Sensors (Basel)
December 2024
Instituto de Automática e Informática Industrial, Universitat Politècnica de València, 46022 Valencia, Spain.
In this paper, a bibliometric review is conducted on brain-computer interfaces (BCI) in non-invasive paradigms like motor imagery (MI) and steady-state visually evoked potentials (SSVEP) for applications in rehabilitation and robotics. An exploratory and descriptive approach is used in the analysis. Computational tools such as the biblioshiny application for R-Bibliometrix and VOSViewer are employed to generate data on years, sources, authors, affiliation, country, documents, co-author, co-citation, and co-occurrence.
View Article and Find Full Text PDFKnowing is Half the Battle: The Factors Leading to Efficient Recruitment of Representative Samples in Schizophrenia Research.
Pharmaceut Med
January 2025
New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
Background And Objectives: Drug development in schizophrenia is limited by the differential scaling of the active treatment and placebo arms of a study, such that, as the number of sites increases, the magnitude of placebo response disproportionately increases. The objective of this article was to identify factors conducive to efficient recruitment as a step towards trial designs allowing recruitment of more participants per site, leading to reduced variability, and potentially a smaller placebo effect.
Patients And Methods: Using the information of 554 individuals, we calculated the percentage of individuals who were screened, consented, and retained in our research, along with rationale for nonconsent.
Late development of sensory thresholds for horizontal relative disparity in human visual cortex in the face of precocial development of thresholds for absolute disparity.
J Neurosci
January 2025
Department of Psychology, 450 Jane Stanford Way, Stanford University, Stanford, CA, USA.
Immaturities exist at multiple levels of the developing human visual pathway, starting with immaturities in photon efficiency and spatial sampling in the retina and on through immaturities in early and later stages of cortical processing. Here we use Steady-State Visual Evoked Potentials (SSVEPs) and controlled visual stimuli to determine the degree to which sensitivity to horizontal retinal disparity is limited by the visibility of the monocular half-images, the ability to encode absolute disparity or the ability to encode relative disparity. Responses were recorded from male and female human participants at average ages of 5.
View Article and Find Full Text PDFResearch on the construction of an urban underground parking space color system from the perspective of psychological perception.
PLoS One
January 2025
College of Architecture and Civil Engineering, Xi'an University of Science and Technology, Xi'an, Shaanxi, P. R. China.
Color, an intuitive element affecting human senses, can adapt to the environment of a space, evoke emotional responses, trigger and accumulate visual experiences, and enhance the effectiveness of color in shaping spatial atmosphere and reinforcing spatial divisions. In the context of rapid urban underground space development, examining the rational application of color in underground parking spaces is crucial for improving guidance, comfort, and aesthetics. This exploration is essential for achieving high-quality development in urban underground parking environments.
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