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Aims: Periprosthetic fractures (PPFs) following hip arthroplasty are complex injuries. This study evaluates patient demographic characteristics, management, outcomes, and risk factors associated with PPF subtypes over a decade.
Methods: Using a multicentre collaborative study design, independent of registry data, we identified adults from 29 centres with PPFs around the hip between January 2010 and December 2019. Radiographs were assessed for the Unified Classification System (UCS) grade. Patient and injury characteristics, management, and outcomes were compared between UCS grades. A multinomial logistic regression was performed to estimate relative risk ratios (RRR) of variables on UCS grade.
Results: A total of 1,104 patients were included. The majority were female (57.9%; n = 639), ethnically white (88.5%; n = 977), used mobility aids (67%; n = 743), and had a median age of 82 years (interquartile range (IQR) 74 to 87). A total of 77 (7%) had pain prior to the PPF. The most common UCS grade was B2 (33%; n = 368). UCS type D fractures had the longest length of stay (median 19 days (IQR 11 to 26)), highest readmission to hospital (21%; n = 9), and highest rate of discharge to step-down care (52%; n = 23). Multinomial regression suggests that uncemented femoral stems are associated with a reduced risk of UCS C (RRR 0.36 (95% confidence interval (CI) 0.2 to 0.7); p = 0.002) and increased risk of UCS A (RRR 3.3 (95% CI 1.9 to 5.7); p < 0.001), compared to UCS B fracture.
Conclusion: The most common PPF type in elderly frail patients is UCS B2. Uncemented stems have a lower risk of UCS C fractures compared to cemented stems. A national PPF database is needed to further identify correlation between implants and fracture subtypes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471444 | PMC |
http://dx.doi.org/10.1302/2633-1462.49.BJO-2023-0065.R1 | DOI Listing |
Hum Vaccin Immunother
December 2025
Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
In recent years, several clinical trials focused on the potential role of immune-checkpoint inhibitors (ICIs) in the adjuvant treatment of muscle-invasive urothelial cancer (UC). Heretofore, only the anti-programmed death protein 1 (anti-PD1) nivolumab received European Medical Agency (EMA) approval for cisplatin-unfit patients. In our work, we deeply analyzed the results of the three pivotal studies in view of the rapidly evolving therapeutic advanced UC's scenario.
View Article and Find Full Text PDFOral Dis
December 2024
Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Background: The variability in patients' risk of oral mucositis (OM) has been, in part, attributed to differences in host genomics. The aim better define the role of genomics as an OM risk by investigating the association between genetic variants and the presence and severity of OM in pediatric patients with osteosarcoma (OS) undergoing chemotherapy (CT).
Methods: A longitudinal observational retrospective study was conducted.
Comp Immunol Microbiol Infect Dis
November 2024
Simbios Biotecnologia, Cachoeirinha, RS, Brazil; Veterinary Medicine Diagnostic Laboratory (LDMV), Institute of Biotechnology (IB), Postgraduate Programs in Animal Health (PPGSA) and Biotechnology (PPGBIO), University of Caxias do Sul (UCS), Caxias do Sul, RS, Brazil. Electronic address:
Feline immunodeficiency virus (FIV) is a retrovirus affecting domestic cats worldwide and causing immunosuppression and reduced quality of life. The prevalence of FIV infection varies according to geographic regions / countries and it is associated with domestic cat health managements (vaccination, neutering, basic health care, etc.).
View Article and Find Full Text PDFChildren (Basel)
November 2024
Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, 50406 Tartu, Estonia.
: There are strict demands on body weight and shape in highly trained adolescent female athletes, and they are in the highest risk group for the development of eating disorders. This study aims to compare the behavioural eating patterns between highly trained female adolescent athletes and untrained controls (UCs), and to describe the associations between behavioural eating patterns and different energy homeostasis hormones. : A total of 33 rhythmic gymnasts (RGs), 20 swimmers (SWs), and 20 UCs ( = 20) that were 14 to 18 years old participated in this investigation.
View Article and Find Full Text PDFJ Bodyw Mov Ther
October 2024
University of Caxias Do Sul, Caxias Do Sul, Brazil. Electronic address:
Introduction: Pregnancy's physiological changes and weight gain can decrease balance control, increasing the risk of falls and impacting quality of life. The effect of obesity on balance control in pregnant women needs further investigation.
Objective: Investigate the effect of obesity during pregnancy on center of pressure (COP) control under sensory disturbances at different gestational age.
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