An and study on extracorporeal transducer optimization for high-intensity focused ultrasound to improve the safety and efficacy of breast tumor ablation.

Objective: To observe the characteristics of a new extracorporeal high intensity focused ultrasound transducer, titled Haifu system JCQ-B, and to compare its safety and efficacy for breast ablation with the standard Haifu system JC transducer.

Materials And Methods: Ox liver with pig skin and pork ribs were prepared in a semi-sphere shape, served as acoustic model. The udders of female goats were used as acoustic model. Both and models were ablated by either JCQ-B or JC transducer. The morphology of biological focal region (BFR), the coagulative necrosis volume, and the temperature increase were observed and compared.

Results: The BFR morphology of JCQ-B transducer was circular both and , with a length-width ratio close to one. Under the same sonication parameters (sonication power, time and depth in tissue), coagulation necrosis volume caused by JCQ-B transducer was larger than that caused by JC transducer both and . The increase in temperature in the near and far acoustic pathways with JCQ-B transducer was significantly lower than that of JC transducer . After receiving high sonication energy during experimentation, there were no complications observed after the ablation of JCQ-B transducer, while small skin damage was observed after the ablation of JC transducer.

Conclusions: The JCQ-B transducer improved the safety and efficacy of treatment by optimizing BFR morphology and ablation efficiency, which could be applied in the treatment of breast tumor.