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Using an Oral Sugar Test to Biologically Validate the Use of a Commercial Enzyme Immunoassay to Measure Salivary Insulin in Western Lowland Gorillas (Gorilla gorilla gorilla).
J Exp Zool A Ecol Integr Physiol
January 2025
Zoological Programs, Cleveland Metroparks Zoo, Cleveland, Ohio, USA.
Noninvasive evaluations of hormones can contribute to the assessment of health and welfare of animals. Variations in insulin levels and sensitivity, for example, have been linked to health concerns in non-human and human primates including insulin resistance, diabetes, and heart disease, the leading cause of death in zoo-housed gorillas. Few published studies have assessed insulin concentrations in western lowland gorillas (Gorilla gorilla gorilla), and all did so using serum.
View Article and Find Full Text PDFUnveiling Cuproptosis-Driven Molecular Clusters and Immune Dysregulation in Ankylosing Spondylitis.
J Inflamm Res
January 2025
Department of Rheumatism and Immunity, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Background: Ankylosing spondylitis (AS) is a chronic autoimmune disease characterized by inflammation of the sacroiliac joints and spine. Cuproptosis is a newly recognized copper-induced cell death mechanism. Our study explored the novel role of cuproptosis-related genes (CRGs) in AS, focusing on immune cell infiltration and molecular clustering.
View Article and Find Full Text PDFClinical significance of retrograde inferior parathyroid protection technique based on thymus preservation in thyroid surgery.
BMC Endocr Disord
January 2025
The Department of Thyroid Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, 350001, China.
Background: The importance of parathyroid gland preservation in thyroid surgery has been well recognized; however, the rapid identification of the parathyroid gland, particularly the inferior parathyroid gland (IPG), remains challenging. This study aimed to evaluate the effectiveness of retrograde inferior parathyroid protection technique (RIPPT) based on thymus preservation.
Methods: A total of 236 patients were enrolled in this study between August 2019 and December 2020.
A-D-A type fluorescent probe with dual quaternary-ammonium-salt anchors for turn on detection of HSA in wide emission gamut.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122 China. Electronic address:
Human serum albumin (HSA) is a key protein implicates in various physiological and pathological conditions such as renal injury, diabetes mellitus. Herein, we report an AIE-active fluorescent probe (DNI-4) for detection of HSA with a "turn on" response covering visible and near-infrared region (500 - 800 nm). Combining with a triphenylamine and two 1,8-naphthalimide moieties, the chromophore segment of DNI-4 forms a "A-D-A" type molecular architecture with the twisted intramolecular charge transfer property.
View Article and Find Full Text PDFBaseline Vitamin D Levels on Quality of Life and Pain Perception Among Patients with Chronic Pain with Long-Term Prescription Opioid Use: A Prospective Study.
J Clin Med
January 2025
Clinic of Anaesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, LT-03101 Vilnius, Lithuania.
To investigate the correlation between baseline serum concentrations of 25-hydroxyvitamin D (25-OHD) and quality of life (QoL), as well as pain perception in patients with chronic pain with long-term prescription opioid usage before opioid detoxification. We prospectively studied 45 patients with chronic pain with long-term prescription opioid usage who were selected for elective detoxification. Baseline serum 25-OHD levels were measured prior to detoxification, classifying patients as either vitamin D deficient (<75 nmol/L) or sufficient (≥75 nmol/L).
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