The Biostimulant E-50 preparation, a biogenic stumulant, was applied to 8 bulls divided into two groups--with normal and with disturbed semen production (lower qualitative indices of semen and higher number of discarded ejaculates). The stimulant was injected muscularly at the rate of 40 cu. cm, twice, at a seven-day interval, with one of the bulls it being used in a second series. Studied were a total of 587 ejaculates taken from the test bulls following treatment. It was found that the agent produced a favourable effect on semen production, the reaction being individual and better manifested with bulls having disturbances. Up to 13.7 per cent of the ejaculates of bulls with normal semen production were discarded, and up to 31.8 per cent of those showing signs of disturbed spermiogenesis. The spermogram indices with some bulls reliably rose (P less than 0.01 and 0.05) in terms of concentration and motility, the number of dead spermatozoa coming back to normal at negligible rise of the pH value.
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Mol Biol Rep
January 2025
Center for Environmental and Human Toxicology, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Reproduction in males is one of the complicated processes that is mediated by many environmental factors, as well as by diet (e.g. supplements, nutritional value).
View Article and Find Full Text PDFBMJ Open
January 2025
Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore
Introduction: Despite the global prevalence of low fertility rates, male contributions to fertility and reproductive health outcomes have been understudied. This study aims to investigate the male contribution to fertility and explore the underlying biological mechanisms. Specifically, we aim to (1) identify male factors associated with successful pregnancy, (2) develop a fertility index incorporating modifiable factors for both males and females to predict pregnancy rate and (3) explore the relationship of male modifiable factors with semen parameters and molecular characteristics.
View Article and Find Full Text PDFTheriogenology
January 2025
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Cryopreservation of rooster semen is a reproductive technology carried out to boost genetic gain and productivity in commercial flocks of chicken. However, semen freezing significantly reduces the quality and fertilizing potential of spermatozoa. This study examined cryoprotective effects of the mitochondria-targeted antioxidant mitoquinol mesylate added to the freezing extender by assessing post-thaw characteristics of rooster sperm.
View Article and Find Full Text PDFAndrology
January 2025
Department of Urology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Background: Direct-to-consumer (DTC) semen analysis (SA) products obviate barriers that deter men from clinic testing and have made strides in providing higher quality data. However, it is unclear how well these products adhere to the 2021 WHO guidelines on examination and processing of human spermatozoa as they pertain to the evaluation of male fertility.
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Toxicon
January 2025
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Electronic address:
Strychni Semen is the dried ripe seeds of the plant Strychnos nux-vomica L, and has great medicinal value and developmental potential.However, Strychni Semen is severely toxic, with adverse effects on the central nervous system, urinary system, and other organ systems, and severe cases can be life-threatening. The present study was to reveal the mechanism of nephrotoxicity induced by Strychni Semen and its alkaloid components using experiments.
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