AI Article Synopsis
- - The study aimed to compare the effectiveness and side effects of accelerated hyperfractionation (AHF) versus once-daily fractionation (ODF) in treating stage 1 glottic carcinoma (GC) with a focus on local control rates.
- - A total of 102 patients were analyzed retrospectively, with the 5-year local control rate being 98% for the AHF group compared to 91% for the ODF group, which showed no significant difference (p=0.19).
- - However, patients in the AHF group experienced more severe side effects, requiring opioids for mucositis significantly more (74% vs. 25%) and had a tendency for a higher risk of aspiration
Article Abstract
Background/aim: Accelerated hyperfractionation (AHF) is used in head and neck cancer to improve the local control (LC) rate, but reports of outcomes for early-stage GC are limited. The outcomes of radiotherapy (RT) for stage 1 glottic carcinoma (GC) were retrospectively analyzed, comparing AHF and once-daily fractionation (ODF) using 2.0-2.4 Gy.
Patients And Methods: A total of 102 patients with stage 1 GC underwent RT alone between 2007 and 2021, with 43 in the AHF group and 59 in the ODF group. A p-value less than 0.05 was considered to indicate a significant difference.
Results: The 5-year LC rate was 98% in the AHF group and 91% in the ODF group (p=0.19). During RT, significantly more patients in the AHF group required opioids due to mucositis than in the ODF group (74% vs. 25%, p<0.001), and the rate of aspiration pneumonia tended to be higher in the AHF group than in the ODF group (7% vs. 0%, p=0.072).
Conclusion: There was no difference in the LC rate between AHF and ODF for stage 1 GC. Moreover, the AHF group required opioids at a higher rate and tended to have a higher risk of developing aspiration pneumonia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500519 | PMC |
| http://dx.doi.org/10.21873/invivo.13335 | DOI Listing |
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