AI Article Synopsis

  • The study aimed to determine the optimal cutoff point for Ki-67 in breast cancer and its relationship with other tumor characteristics and patient outcomes.
  • Data from 609 patients with specific breast cancer subtypes were analyzed, finding a 30% cutoff point for Ki-67 that significantly influenced recurrence-free survival.
  • Patients with Ki-67 values of 30% or lower exhibited better prognosis and reduced tumor malignancy, establishing 30% as the recommended cutoff for evaluation in this context.

Article Abstract

Objective: Ki-67 is associated with breast cancer subtypes, but the optimal cutoff point of Ki-67 has not been established in our center. We evaluated the cutoff point of Ki-67 in breast cancer and analyzed the associations among Ki-67, clinicopathological features, and prognosis.

Methods: The clinicopathological data and prognostic information of patients with breast cancer treated in our center were retrospectively collected, and the optimal cutoff point of Ki-67 was determined by univariate and multivariate survival risk analyses. The cutoff point was used to group the patients, and the differences in the clinicopathological features and prognosis were analyzed between the two groups.

Results: In total, 609 patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative primary breast cancer were enrolled. The mean Ki-67 value was 22.3% ± 15.4%, the median was 20%, and a cutoff point of 30% was an independent factor influencing recurrence-free survival. When 30% was used as the cutoff point, patients with a Ki-67 value of ≤30% had a better prognosis and lower tumor malignancy.

Conclusion: The optimal cutoff point of Ki-67 in breast cancer in our center is 30%.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10478558PMC
http://dx.doi.org/10.1177/03000605231195468DOI Listing

Publication Analysis

Top Keywords

cutoff point
32
breast cancer
24
point ki-67
20
optimal cutoff
16
ki-67 breast
12
ki-67
9
cutoff
8
point
8
clinicopathological features
8
breast
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!