Background: Previous investigations have predominantly concentrated on the influence of ozone (O) on general population mortality. However, a noticeable gap exists regarding the attention directed towards susceptible demographics, specifically individuals afflicted by human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS).
Methods: A dataset comprising 1467 AIDS-related fatalities from 2013 to 2020 was amassed from the Hubei Provincial Center for Disease Control and Prevention. Daily maximum 8-h average O levels and meteorological parameters were extracted from the ChinaHighAirPollutants dataset and the National Meteorological Science Data Center, respectively. A time-stratified case-crossover methodology was employed to scrutinize the connection between short-term exposure to O and AIDS-related deaths.
Results: A rise of one interquartile (IQR) in O concentration, lagged by 4 days, was associated with a 15% [95% confidence intervals (CIs): 2, 31] increase in AIDS-related deaths. Notably, males demonstrated heightened susceptibility to the adverse consequences of O, marked by an odds ratio of 1.20 (95% CIs: 1.05, 1.37) at lag 4 day. Additionally, patients aged over 65 years exhibited escalated vulnerability to brief O exposure. Marriage status and educational attainment emerged as influential factors modifying the interplay between O and AIDS-related mortality.
Conclusions: Our study presents novel evidence spotlighting the deleterious repercussions of O on mortality in the HIV/AIDS population.
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| http://dx.doi.org/10.1016/j.ypmed.2023.107689 | DOI Listing |
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