Context: There is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats.
Objective: We evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres.
Materials And Methods: Wistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples were elaborated with immunohistochemistry for Insulin, Glucagon, Ghrelin, and Somatostatin. Glucose and lipid parameters were studied.
Results: In treated animals, Ghrelin and Insulin cells in perybiliary glands (PBGs) were significantly increased. In the male fructose group there was a significant increase of the homeostasis model assessment insulin resistance (HOMA-IR).
Conclusions: Stem/progenitor cells in extrahepatic bile tree (EHBT) could be a source of Insulin-producing cells in metabolic syndrome. Fructose treatment induces the increase of Ghrelin and Insulin cells in PBGs and the elevation of Insulin and Ghrelin plasma concentration.
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| http://dx.doi.org/10.1080/13813455.2023.2252205 | DOI Listing |
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