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| http://dx.doi.org/10.7554/eLife.92367 | DOI Listing |
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From Structure to Function: How Prebiotic Diversity Shapes Gut Integrity and Immune Balance.
Nutrients
December 2024
Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, Brazil.
The microbiota stability, diversity, and composition are pillars for an efficient and beneficial symbiotic relationship between its host and itself. Microbial dysbiosis, a condition where a homeostatic bacterial community is disturbed by acute or chronic events, is a predisposition for many diseases, including local and systemic inflammation that leads to metabolic syndrome, diabetes, and some types of cancers. Classical dysbiosis occurs in the large intestine.
View Article and Find Full Text PDFEffects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial.
Nutrients
December 2024
Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, 41345 Gothenburg, Sweden.
Background/objectives: Correction of decreased diversity of the gut microbiome, which is characteristic of menopause, by supplementation with a synbiotic may attenuate or prevent dysbiosis processes and preserve bone mass. We describe the rationale and design of the OsteoPreP trial aimed at evaluating the effects of 12 months of supplementation with a synbiotic on bone and metabolic health in postmenopausal Caucasian women.
Methods: This is a randomized, double-blinded, placebo-controlled trial among 160 Caucasian, postmenopausal women with no current diagnosis of osteoporosis or supplementation with pro- or prebiotics, and no medical treatment affecting bone turnover.
The role of microbiome in the development of gluten-related disorders.
Best Pract Res Clin Gastroenterol
September 2024
Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, USA. Electronic address:
Gluten-related disorders (GRD) include celiac disease (CD), non celiac gluten sensitivity (NCGS) and wheat allergy (WA), conditions that are associated with the ingestion of gluten-containing food. Gut microbiota composition and function may be involved in the pathogenesis of GRD. In untreated CD the microbiota is characterized by a reduction in beneficial microbes like Lactobacillus and Bifidobacterium and an increase in pathogenic ones such as Bacteroides and E.
View Article and Find Full Text PDFAuthor Correction: Iron sulfide-catalyzed gaseous CO reduction and prebiotic carbon fixation in terrestrial hot springs.
Nat Commun
December 2024
Australian Centre for Astrobiology, University of New South Wales, Sydney, NSW, 2052, Australia.
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