AI Article Synopsis
- Biofilms are a group lifestyle that microbes use to enhance their chances of survival.
- This study focuses on understanding the biofilm matrix, specifically the pathways involved in synthesizing exopolysaccharides (EPS) that form the matrix.
- The research identifies the initial two crucial steps in the EPS synthesis process, laying the groundwork for further exploration and synthesis of related glycan substrates.
Article Abstract
Biofilms are the communal way of life that microbes adopt to increase survival. Key to our ability to systematically promote or ablate biofilm formation is a detailed understanding of the biofilm matrix macromolecules. Here, we identify the first two essential steps in the biofilm matrix exopolysaccharide (EPS) synthesis pathway. Together, our studies and approaches provide the foundation for the sequential characterization of the steps in EPS biosynthesis, using prior steps to enable chemoenzymatic synthesis of the undecaprenyl diphosphate-linked glycan substrates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10653937 | PMC |
| http://dx.doi.org/10.1128/mbio.00948-23 | DOI Listing |
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