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| http://dx.doi.org/10.1093/ehjci/jead224 | DOI Listing |
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Bilateral Breast Involvement in Multiple Myeloma: A Report of a Rare Case.
Cureus
October 2024
Radiology, King Hamad University Hospital, Muharraq, BHR.
Breast plasmacytoma is an uncommon extramedullary manifestation of multiple myeloma (MM). This case presents a primary extramedullary plasmacytoma and progression to MM with breast involvement after 12 years of discovering the disease. The patient is a 54-year-old woman who initially presented with a right humerus pathological fracture that turned out to be a primary extramedullary plasmacytoma.
View Article and Find Full Text PDFMultimodal Imaging Approach to Atrial Myxoma to Optimize Surgical Management.
Cureus
August 2024
Cardiology, Royal Brisbane and Women's Hospital, Brisbane, AUS.
Cardiac masses are rare and of the neoplastic group, myxomas are the most common. An elderly male with a background of multiple myeloma and previous autologous stem cell transplant presented with dyspnea and chest heaviness with a subsequent cardiac mass found. Multimodal imaging, including three-dimensional (3D) echocardiography and cardiac magnetic resonance (CMR) imaging, was utilized to guide the diagnostic process, particularly given the differential of a cardiac plasmacytoma in the setting of multiple myeloma.
View Article and Find Full Text PDFAging aggravates aortic aneurysm and dissection via miR-1204-MYLK signaling axis in mice.
Nat Commun
July 2024
Division of Cardiac Surgery, Cardiovascular Diseases Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.
Article Synopsis
- A study involving 430 participants revealed that the microRNA miR-1204 is significantly higher in elder patients with aortic aneurysm and dissection (AAD) and is linked to aging.
- The mechanism involves cell senescence inducing miR-1204 through p53 interaction, which then causes vascular smooth muscle cell (VSMC) senescence, creating a feedback loop that worsens AAD.
- miR-1204 targets myosin light chain kinase (MYLK), contributing to changes in VSMC phenotypes, and inhibiting miR-1204 shows potential in reducing AAD development in mice, highlighting a possible therapeutic pathway.
Uncommon manifestation of multiple myeloma: A case report of intracardiac plasmacytoma presenting with severe heart failure and bilateral pleural effusion.
Int J Surg Case Rep
January 2024
Tehran University of Medical Sciences, Tehran Heart Center, North Kargar Ave, Tehran Postal code: 1431715673, Iran. Electronic address:
Introduction And Importance: Extramedullary intracardiac plasmacytoma is a rare type of plasma cell neoplasm that involves the heart. This article presents a case report of a patient with this condition and describes the surgical management of the disease.
Case Presentation: The patient was a 65-year-old male with a history of multiple myeloma in remission for two years who presented with shortness of breath and chest pain.
Significant regression of plasmacytoma by cardiac magnetic resonance.
Eur Heart J Cardiovasc Imaging
April 2024
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
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