AI Article Synopsis
- - Type 1 diabetes is an autoimmune disease where the immune system attacks the insulin-producing beta cells in the pancreas, leading to a lifelong need for external insulin.
- - The onset and progression of type 1 diabetes are influenced by both genetic and environmental factors affecting disease initiation and diagnosis.
- - The review discusses how genetic factors, particularly those related to the complement system, may play a significant role in the disease’s progression from pre-clinical stages to full-blown diabetes, based on recent research findings.
Article Abstract
Type 1 diabetes is an autoimmune disease in which one's own immune system destroys insulin-secreting beta cells in the pancreas. This process results in life-long dependence on exogenous insulin for survival. Both genetic and environmental factors play a role in disease initiation, progression, and ultimate clinical diagnosis of type 1 diabetes. This review will provide background on the natural history of type 1 diabetes and the role of genetic factors involved in the complement system, as several recent studies have identified changes in levels of these proteins as the disease evolves from pre-clinical through to clinically apparent disease.
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| http://dx.doi.org/10.1002/dmrr.3716 | DOI Listing |
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